Gels for encapsulation of biological materials
First Claim
1. A coating on a mammalian tissue surface, wherein the coating is formed of a polymer prepared by the free radical photopolymerization of a biocompatible water soluble macromer, initiated by a photoinitiator, that has covalently linked to it at least two free radical-polymerizable substituents, and wherein the tissue is mammalian tissue.
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Accused Products
Abstract
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
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Citations
20 Claims
- 1. A coating on a mammalian tissue surface, wherein the coating is formed of a polymer prepared by the free radical photopolymerization of a biocompatible water soluble macromer, initiated by a photoinitiator, that has covalently linked to it at least two free radical-polymerizable substituents, and wherein the tissue is mammalian tissue.
Specification