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Pharmaceutical composition containing sialic acid derivatives

  • US 5,834,423 A
  • Filed: 03/15/1996
  • Issued: 11/10/1998
  • Est. Priority Date: 07/15/1994
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition characterized by containing as an active ingredient a sialic acid derivative represented by the general formula (1) or (2) below:

  • ##STR15## wherein R1 represents a glycopeptide residue; and

    X1 and X2, which may be identical or different, represent NeuAc(α

    2,6)Gal(β

    1,4)GlcNAc(β

    1,2)-, Gal(β

    1,4)GlcNAc(β

    1,2)-, or GlcNAc(β

    1,2)-, provided that at least one of X1 and X2 represents NeuAc(α

    2,6)Gal(β

    1,4)Glc NAc(β

    1,2)-;

    ##STR16## wherein R2 and R3, which may be identical or different, represent a hydrogen atom or a linear, branched or cyclic, saturated or unsaturated acyl group having 1 to 30 carbon atoms;

    n is an integer of 1 to 20; and

    X3 represents a sialic acid derivative residue or a sialyloligosaccharide derivative residue represented by the general formula (3) below;

    ##STR17## wherein X4 and X5, which may be identical or different, represent NeuAc(α

    2,6)Gal(β

    1,4)GlcNAc(β

    1,2)-, Gal(β

    1,4)GlcNAc(β

    1,2)- or GlcNAc(β

    1,2)-, provided that at least one of X4 and X5 represents NeuAc(α

    2,6)Gal(β

    1,4)Glc NAc(β

    1,2)-; and

    Y represents a sugar residue.

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