Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

• US 5,834,509 A
• Filed: 06/07/1995
• Issued: 11/10/1998
• Est. Priority Date: 12/07/1992
• Status: Expired due to Term

• Current Assignee: Eukarion, Inc.
• Original Assignee: Eukarion, Inc.
• Inventors: Malfroy-Camine, Bernard, Doctrow, Susan Robin
• Primary Examiner(s): Jarvis, William R. A.
• Application Number:
  US08/479,697
• Time in Patent Office: 1,252 Days
• Field of Search: 514/492, 556/32, 556/45
• US Class Current: 514/492
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: C07F 13/005 Compounds without a metal-carbon linkage

Abstract

This invention provides salen-manganese complexes and pharmaceutically acceptable compositions thereof useful as antioxidants and free radical scavengers.

Claims

1. A pharmaceutical composition comprising an antioxidant amount of a salen-metal compound and a pharmaceutically acceptable carrier, excipient or adjuvant, wherein said salen-metal compound is a member selected from the group consisting of:

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2. A pharmaceutical composition of claim 1 wherein said pharmaceutically acceptable carrier is a solid non-toxic carrier.

3. A pharmaceutical composition of claim 1 wherein said salen-metal complex is present in an amount such that said pharmaceutical composition has a predetermined level of superoxide dismutase activity and/or detectable catalase activity per mmol dissolved in an aqueous solution.

4. A salen-metal complex having the structural formula selected from the group of compounds consisting of:

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5. A pharmaceutical aqueous solution comprising a salen-metal complex wherein said salen-metal complex is present in an amount such that said pharmaceutical aqueous solution has a predetermined level of superoxide dismutase activity and/or detectable catalase activity per mmol dissolved in an aqueous solution, and wherein said salen-metal compound is a member selected from the group consisting of:

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