Polyethylene-protein conjugates
First Claim
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1. A physiologically active protein conjugate of the formula ##STR10## wherein R is lower alkyl;
- R2 is O;
R3 is S; and
m and n are selected from any combination of numbers such that the molecular weight of the conjugate excluding the protein is from 300 to 30,000 daltons and the conjugate has at least a portion of the biological activity of the protein which forms the conjugate.
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Abstract
The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein which forms this conjugate.
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Citations
5 Claims
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1. A physiologically active protein conjugate of the formula ##STR10## wherein R is lower alkyl;
- R2 is O;
R3 is S; and m and n are selected from any combination of numbers such that the molecular weight of the conjugate excluding the protein is from 300 to 30,000 daltons and the conjugate has at least a portion of the biological activity of the protein which forms the conjugate. - View Dependent Claims (2, 3, 4, 5)
- R2 is O;
Specification
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Current AssigneeHoffmann-La Roche Incorporated (Roche Holding AG)
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Original AssigneeHoffmann-La Roche Incorporated (Roche Holding AG)
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InventorsRosen, Perry, Hakimi, John, Kilian, Patricia
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Primary Examiner(s)Sayala, Chhaya D.
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Application NumberUS08/457,068Time in Patent Office1,258 DaysField of Search530/351, 530/403, 530/405, 530/409, 424/85.4, 424/85.7, 514/12, 435/188US Class Current530/351CPC Class CodesA61K 47/60 the organic macromolecular ...A61P 37/00 Drugs for immunological or ...A61P 37/02 ImmunomodulatorsA61P 43/00 Drugs for specific purposes...Y10S 435/964 including enzyme-ligand con...Y10S 530/816 Attached to the carrier via...
