Seals for use in an aerosol delivery device

• US 5,836,299 A
• Filed: 02/28/1995
• Issued: 11/17/1998
• Est. Priority Date: 07/15/1993
• Status: Expired due to Term

• Current Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Kwon, Oh-Seung
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US08/397,546
• Time in Patent Office: 1,358 Days
• Field of Search: 424/43, 424/45, 424/47, 222/373, 222/402, 222/398, 222/394, 222/402.1, 222/395, 222/399, 222/372, 239/338, 252/305, 128/200.23, 128/200.14
• US Class Current: 128/200.23
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
• CPC Class Codes: B65D 83/54 Metering valves ; Metering valve assemblies
• CPC Class Codes: C09K 2200/062 Polyethylene
• CPC Class Codes: C09K 2200/0622 Polyvinylalcohols, polyvinylacetates
• CPC Class Codes: C09K 2200/0642 Copolymers containing at least three different monomers
• CPC Class Codes: C09K 3/10 Materials in mouldable or extrudable form for sealing or packing joints or covers filling pastes C09D5/34
• CPC Class Codes: C09K 3/30 for aerosols aerosol containers B65D83/14

Abstract

A device for delivering an aerosol, comprising: a casing member, a valve stem, and a diaphragm. The diaphragm is made of an ethylene-propylene-diene rubber ("EPDM") and is stable to dimensional change when exposed to 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoroethane.

Claims

1. A device for delivering an aerosol, comprising:

a valve stem, a diaphragm comprising an ethylene-propylene-diene rubber free of silicone adhesive agents and having walls defining a diaphragm aperture, and a casing member having walls defining a formulation chamber and a casing aperture, wherein the valve stem passes through the diaphragm aperture and the casing aperture and is in slidable sealing engagement with the diaphragm aperture, and wherein the diaphragm is in sealing engagement with the casing member, the device having contained in the formulation chamber thereof a medicinal aerosol formulation wherein the medicinal aerosol formulation comprises 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane.

2. A device according to claim 1 wherein the diaphragm is stable to dimensional change when exposed to the medicinal aerosol formulation.

3. A device according to claim 1, wherein the ethylene-propylene-diene rubber is the only polymer component of the diaphragm.

4. A device according to claim 1, wherein the ethylene-propylene-diene rubber is present in the form of particles dispersed in a continuous thermoplastic matrix.

5. A device according to claim 4, wherein the thermoplastic matrix comprises polypropylene or polyethylene.

6. A device according to claim 2, wherein the ethylene-propylene-diene rubber is the only polymer component of the diaphragm.

7. A device according to claim 2, wherein the ethylene-propylene-diene rubber is present in the form of particles dispersed in a continuous thermoplastic matrix.

8. A device according to claim 7, wherein the thermoplastic matrix comprises polypropylene or polyethylene.