Transcutaneous non-bloody determination of the concentration of substances in the blood
First Claim
1. A method for transcutaneous and non-bloody in vivo determination of an analyte in blood, comprising:
- (a) spectroscopically generating at least one first signal corresponding to at least one analyte quantity in a region of a body and at least one second signal corresponding to at least one water quantity in the region of the body;
(b) determining the at least one analyte quantity based on the at least one first signal and determining the at least one water quantity based on the at least one second signal;
(c) calculating a concentration of the analyte in water by forming a ratio of a value related to the at least one analyte quantity and a value related to the at least one water quantity; and
(d) calculating a concentration of the analyte in blood based on the ratio.
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Abstract
Methods for transcutaneous and non-bloody in vivo determination of an analyte in blood which includes spectroscopically generating at least one first signal corresponding to at least one analyte quantity in a region of a body and at least one second signal corresponding to at least one water quantity in the region of the body, determining the at least one analyte quantity based on the at least one first signal and the at least one water quantity based on the at least one second signal, calculating a concentration of the analyte in water by forming a ratio of an analyte value calculated on the basis of the at least one analyte quantity and a water value calculated on the basis of the at least one water quantity and calculating a concentration of the analyte in blood based on the ratio of the analyte value and the water value.
42 Citations
20 Claims
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1. A method for transcutaneous and non-bloody in vivo determination of an analyte in blood, comprising:
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(a) spectroscopically generating at least one first signal corresponding to at least one analyte quantity in a region of a body and at least one second signal corresponding to at least one water quantity in the region of the body; (b) determining the at least one analyte quantity based on the at least one first signal and determining the at least one water quantity based on the at least one second signal; (c) calculating a concentration of the analyte in water by forming a ratio of a value related to the at least one analyte quantity and a value related to the at least one water quantity; and (d) calculating a concentration of the analyte in blood based on the ratio. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for transcutaneous and non-bloody in vivo determination of an analyte in blood, comprising:
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(a) spectroscopically generating a signal corresponding to an analyte quantity at diastole and a signal corresponding to an analyte quantity at systole in a region of a body; (b) determining the analyte quantity at diastole based on the signal corresponding to the analyte quantity at diastole and determining the analyte quantity at systole based on the signal corresponding to the analyte quantity at systole; (c) spectroscopically generating a signal corresponding to a water quantity at diastole and a signal corresponding to a water quantity at systole in a region of a body; (d) determining the water quantity at diastole based on the signal corresponding to the water quantity at diastole and determining the water quantity at systole based on the signal corresponding to the water quantity at systole; (e) calculating a ratio of a difference of the analyte quantity at diastole and the analyte quantity at systole and a difference of the water quantity at diastole and the water quantity at systole; and (f) multiplying the ratio by a correction factor for percentage portion of water in blood. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification