Method of inhibiting restenosis by applying ultrasonic energy
First Claim
1. A method of inhibiting restenosis in mammals, comprising:
- treating a stenosis of a blood vessel of a mammal, said treatment causing injury to the vessel wall in the region of the stenosis;
applying ultrasound within the vessel to cause cavitation within the vessel in the region of the injury and irradiating smooth muscle cells in the region of the injury with sufficient ultrasound energy to reduce the migration capacity of the smooth muscle cells at least about 2.4 fold without the use of restenosis inhibiting drugs.
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Abstract
A method and system for inhibiting restenosis by compromising the migration, viability and adhesion of mammalian smooth muscle cells (SMC) is disclosed. The method comprises irradiating the SMC with ultrasonic energy, in an amount which has been found to be effective in inhibiting the migration and adherence of SMC. This method is especially useful in the prevention of restenosis in a blood vessel of a mammal associated with the migration of SMC in the blood vessel following vascular intervention, such as angioplasty. The system disclosed for the prevention of restenosis in a blood vessel of a mammal associated with the migration of SMC in the blood vessel following vascular intervention includes an ultrasonic energy source; a transmitter for transmitting the ultrasonic energy to the blood vessel; and a control unit.
177 Citations
16 Claims
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1. A method of inhibiting restenosis in mammals, comprising:
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treating a stenosis of a blood vessel of a mammal, said treatment causing injury to the vessel wall in the region of the stenosis; applying ultrasound within the vessel to cause cavitation within the vessel in the region of the injury and irradiating smooth muscle cells in the region of the injury with sufficient ultrasound energy to reduce the migration capacity of the smooth muscle cells at least about 2.4 fold without the use of restenosis inhibiting drugs. - View Dependent Claims (2, 3, 4, 5, 6, 15, 16)
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7. A therapeutic method for the prevention of restenosis associated with smooth muscle cell migration and adherence in a blood vessel of a mammal following vascular intervention, comprising:
exposing smooth muscle cells in a blood vessel to sufficient ultrasonic energy to reduce the migration capacity of the smooth muscle cells without the use of restenosis inhibiting drugs, at least about 2.4 fold. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
Specification