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Apparatus and methods for gene therapy

  • US 5,836,905 A
  • Filed: 12/27/1996
  • Issued: 11/17/1998
  • Est. Priority Date: 06/20/1994
  • Status: Expired due to Term
First Claim
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1. A catheter for transferring medical material in vivo to a target tissue comprising:

  • an elongated hollow flexible tubular member adapted to be inserted within a blood vessel;

    an operating head attached to said tubular member and containing a particle bombardment device disposed therein for discharging particles coated with medical material so that particles impinge in vivo on target tissue and deliver the medical material intracellularly thereto;

    a discharge port disposed on said operating head out through which are discharged said particles wherein said operating head further comprises telescoping proximal and distal sections which act to seal and unseal said discharge port;

    a hydraulic cylinder within said operating head for moving one of said telescoping sections with respect to the other so as to seal and unseal said discharge port;

    proximal and distal balloons girthing said tubular member supported adjacent said operating head; and

    a balloon inflation line running through said tubular member and communicating with said proximal and distal balloons so as to provide inflation pressure thereto wherein inflation of said proximal and distal balloons against the walls of an artery or other body duct in which said catheter is inserted serves to isolate a space therebetween into which coated particles may be discharged from said operating head toward a target tissue.

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