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Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release

  • US 5,837,747 A
  • Filed: 04/28/1994
  • Issued: 11/17/1998
  • Est. Priority Date: 10/29/1991
  • Status: Expired due to Term
First Claim
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1. A modified biocompatible material having the formula:

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    space="preserve" listing-type="equation">A--Xwherein;

    a) A is a biocompatible starting material selected from a polysaccharide, polycation, or lipid;

    b) X is a moiety containing a carbon--carbon double bond or triple bond capable of undergoing free radical polymerization;

    c) A and X are linked covalently through linkages selected from ester, ether, thioether, disulfide, amide, secondary amines, tertiary amines, direct C--C linkages, sulfate esters, sulfonate esters, phosphate esters, urethanes, or carbonates;

    d) said modified biocompatible material forms covalent crosslinks when subjected to biocompatible, free radical polymerization producing conditions in aqueous media consisting essentially of water and solutes, or consisting essentially of water, solutes, and a biocompatible oil; and

    e) A--X is produced in aqueous media consisting essentially of water and solutes.

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