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Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds

  • US 5,837,860 A
  • Filed: 03/05/1997
  • Issued: 11/17/1998
  • Est. Priority Date: 03/05/1997
  • Status: Expired due to Term
First Claim
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1. A method for the covalent attachment of nucleic acid molecules to a solid-phase, which comprises the steps of:

  • A) coating a solid-phase surface with a mercaptosilane wherein said mercaptosilane comprises sulfhydryl groups; and

    B) coupling a sulfhydryl or disulfide modified nucleic acid molecule to the sulfhydryl groups of said mercaptosilane by means of a covalent disulfide bond.

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