Nitric oxide treatment
First Claim
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1. An apparatus for carrying out the treatment of a patient with nitric oxide in connection with one of a lung disease or condition of the type that can be treated by the administration of gaseous nitric oxide by inhalation, the apparatus comprising:
- means for supplying gaseous nitric oxide from a source thereof to the patient substantially free of any respiratory gas for inhalation thereby, the supply means incorporating regulator means to control the egress of nitric oxide from the source;
means to monitor the patient'"'"'s respiration; and
control means for controlling the regulator to cause the egress from the source of a very short pulse of nitric oxide of a known, predetermined duration at a predetermined instant during an inhalation, the pulse having a duration less than a duration of the inhalation, whereby the nitric oxide is delivered specifically to the site of interest in the patient'"'"'s lung.
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Abstract
The invention is a method and apparatus for treatment in which nitric oxide is supplied from a source to a patient for inhalation incorporating a regulator to control the flow of nitric oxide from the source to the patient, a monitoring apparatus to monitor the patient'"'"'s respiration, and a controller to cause the regulator to permit the egress of a very short pulse of nitric oxide of a known, predetermined volume at a predetermined time during the patient'"'"'s inhalation.
235 Citations
22 Claims
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1. An apparatus for carrying out the treatment of a patient with nitric oxide in connection with one of a lung disease or condition of the type that can be treated by the administration of gaseous nitric oxide by inhalation, the apparatus comprising:
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means for supplying gaseous nitric oxide from a source thereof to the patient substantially free of any respiratory gas for inhalation thereby, the supply means incorporating regulator means to control the egress of nitric oxide from the source; means to monitor the patient'"'"'s respiration; and control means for controlling the regulator to cause the egress from the source of a very short pulse of nitric oxide of a known, predetermined duration at a predetermined instant during an inhalation, the pulse having a duration less than a duration of the inhalation, whereby the nitric oxide is delivered specifically to the site of interest in the patient'"'"'s lung. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for treatment of a patient with nitric oxide in connection with a condition of the type that can be treated by the administration of gaseous nitric oxide by inhalation, the method comprising the steps of:
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monitoring the patient'"'"'s respiration; administering nitric oxide to the patient at a concentration sufficient to have a desired therapeutic effect intermittently and in very short pulses of known, predetermined duration less than a duration of the patient'"'"'s respiration and substantially free of any respiratory gas at a specified instant in the patient'"'"'s respiration as appropriate to treat the condition. - View Dependent Claims (10, 11, 12, 13, 14)
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15. An apparatus for treatment of a patient with nitric oxide comprising:
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a source of gaseous nitric oxide; a regulator coupled to the source to control the flow of the nitric oxide from the source to the patient; a monitor for monitoring the patient'"'"'s respiration; and control means responsive to the monitor for controlling the regulator to cause the flow from the source of a very short pulse of nitric oxide of a known, predetermined duration less than a duration of the patient'"'"'s respiration and at a predetermined instant during the patient'"'"'s respiration, whereby the nitric oxide is delivered specifically to the site of interest in the patient'"'"'s lung substantially free of any respiratory gas. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification