Radioisotope stent with increased radiation field strength at the ends of the stent

• US 5,840,009 A
• Filed: 12/05/1995
• Issued: 11/24/1998
• Est. Priority Date: 12/05/1995
• Status: Expired due to Fees

• Current Assignee: Isostent, Inc. (Cardinal Health, Inc.)
• Original Assignee: Isostent, Inc. (Cardinal Health, Inc.)
• Inventors: Fischell, David R., Fischell, Robert E., Fischell, Tim A.
• Primary Examiner(s): Lacyk, John P.
• Application Number:
  US08/567,138
• Time in Patent Office: 1,085 Days
• Field of Search: 600/1-8, 606/78, 606/108, 606/191, 606/194, 606/195, 606/198
• US Class Current: 600/3
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2210/0095 radioactive
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

Disclosed is a radioisotope stent that has increased radioactivity at the end regions of the stent as compared to the stent'"'"'s central region. To minimize the neointimal hyperplasia that may exist to a greater extent at the ends of a stent that is implanted into an artery of a human body, the amount of radioactivity placed at or near the ends of the stent should be increased as compared to the amount of radioactivity over the remainder of the stent. It is an additional object of this invention to increase the radiation field at the end of a radioisotope stent by placing additional metal surfaces at the ends of the stent so as to have additional surfaces onto which a radioisotope can be placed.

Claims

1. A radioisotope stent comprising a generally cylindrical, thin-walled, metal structure, the stent having an end region near each end of the stent and a central region located generally at the longitudinal center of the stent, the stent including a radioactive material which is a radioisotope, the radioisotope being fixedly joined to the metal of the stent, the stent also having a greater amount of a radioisotope per unit length of the stent at the end regions of the stent compared to a lesser amount of radioisotope per unit length at the central region of the stent.

2. The stent of claim 1 wherein the amount of radioisotope per unit length of stent continuously increases towards the ends of the stent from some point between the center of the stent and the end of the stent, the amount of radioisotope per unit length of stent reaching a maximum amount of radioisotope per unit length at the ends of stent.

3. The stent of claim 1 wherein the radioisotope that is fixedly joined to the stent is a beta-particle emitting radioisotope.

4. The stent of claim 3 wherein the radioisotope is phosphorous 32.

5. The stent of claim 1 wherein the stent is coated with an antithrombogenic coating.

6. The stent of claim 1 wherein the stent is adapted to be expanded by an inflatable balloon.

7. The stent of claim 1 wherein the stent is adapted to be self-expanding.

8. The stent of claim 1 wherein the metal of the stent has a surface and at least some of the radioisotope is plated onto the surface of the stent to form a surface coating.

9. The stent of claim 1 wherein metal of the stent has a surface and the stent has at least some of the radioisotope ion implanted into the metal of the stent to form a radioactive stent in which the ions of the radioisotope are buried just beneath the surface of the stent.

10. The stent of claim 1 wherein the end region of the stent has more surface area per unit length of the stent as compared to the surface area per unit length of the stent at the stent'"'"'s central region, the stent having a generally uniform amount of radioisotope per unit surface area of the stent thus providing an increased amount of radioisotope per unit length of the stent at the stent'"'"'s end regions.