Guidewire having hydrophilic coating

• US 5,840,046 A
• Filed: 06/21/1996
• Issued: 11/24/1998
• Est. Priority Date: 06/21/1996
• Status: Expired due to Fees

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Deem, Mark E.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): WINGOOD, PAMELA LYNN
• Application Number:
  US08/665,973
• Time in Patent Office: 886 Days
• Field of Search: 128/772, 128/652, 128/658, 604/95, 604/96, 604/280, 604/281, 604/282
• US Class Current: 600/585
• CPC Class Codes: A61M 2025/09091 where a sheath surrounds the coil at the distal part
• CPC Class Codes: A61M 2025/09175 having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 Guide wires

Abstract

A guidewire comprises a core wire having a coil tip at its distal end. The coil tip includes a helically wound filament having adjacent turns spaced apart by a preselected distance. The guidewire is coated with a polymeric material, typically a hydrophilic polysaccharide, such as hyaluronic acid or chondroitin sulfate. By properly selecting the spacing between adjacent turns of the coil tip, the hydrophilic coating will adhere to the coil tip in a manner which does not penetrate the coil and which does not significantly interfere with flexibility and bendability of the coil tip.

Claims

1. A guidewire comprising:

a core wire having a proximal end and a distal end;

a coil disposed over a distal portion of the core wire, wherein the coil comprises a helically wound filament having a plurality of successive turns spaced-apart by a distance of from 15% to 50% of the width of the filament; and

a polymeric coating bridging the space between successive turns of the helical filament of the coil, wherein said space allows the coating to flex and accommodate bending of the coil without significant loss of pliability.

2. A guidewire as in claim 1, wherein the polymeric coating is a hydrophilic polymer.

3. A guidewire as in claim 2, wherein the hydrophilic polymer is a polysaccharide selected from the group consisting of hyaluronic acid and chondroitin sulfate.

4. A guidewire as in claim 3, wherein the filament has a circular cross-section with a diameter in the range from 0.02 mm to 0.1 mm, a spacing between adjacent turns in the range from 0.003 mm to 0.05 mm, and wherein the thickness of the polysaccharide coating is in the range from 0.025 μ

m to 0.5 mm.

5. A guidewire as in claim 1, wherein the distal portion of the core wire is spaced radially inward from the coil to create an annular gap between the core wire and an interior surface of the coil.

6. A guidewire as in claim 5, wherein the polymeric coating does not penetrate into the annular gap.

7. A guidewire as in claim 1, wherein the core wire is composed of a material selected from the group consisting of stainless steel, nickel titanium alloy, and tantalum.

8. A guidewire as in claim 1, wherein the coil filament is composed of material selected from the group consisting of platinum, a platinum-iridium alloy, gold, stainless steel, and tantalum.