Solid state fluid delivery system

• US 5,840,062 A
• Filed: 11/08/1995
• Issued: 11/24/1998
• Est. Priority Date: 11/08/1995
• Status: Expired due to Term

• Current Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: Microdose Technologies Inc. (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Fleming, Scott, Gumaste, Anand V., Abrams, Andrew L.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US08/555,207
• Time in Patent Office: 1,112 Days
• Field of Search: 604/20, 604/30-34, 604/50, 604/52, 604/53, 604/65-67, 604/246-249, 128/DIG. 12, 128/13
• US Class Current: 604/68
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: F04B 43/046 with piezoelectric drive

Abstract

An apparatus and method are disclosed that utilize piezoelectric materials as part of a delivery system capable of the rapidly repetitive dispensing of a fluid to an intended target site. In a particular embodiment, the appartus contemplates a solid state needleless injection system which comprises a first housing structure having a dispensing chamber of variable volume capacity and at least one nozzle element for fluid discharge, and a fluid reservoir operatively connected to the first housing structure, and a second housing structure containing at least one piezoelectric actuator. A valve means is disposed between the fluid reservoir and the dispensing chamber to control the flow of said fluid therebetween. The fluid which may be a medication, is forced out of the dispensing chamber through an injection port upon actuation of the piezoelectric actuator. The piezoelectric actuator interacts with the dispensing chamber in such a manner that the overall capacity of the dispensing chamber may be altered by altering the degree of actuation of the piezoelectric actuator.

Claims

1. An apparatus for the rapid and repeatable delivery of small quantities of a fluid to an intended target, comprising:

at least one first housing having walls defining a dispensing chamber for said fluid, and at least one nozzle element defined in one of said walls for the discharge of said fluid; and

at least one second housing communicating with said first housing, said second housing comprising pump means comprising at least one piezoelectric element in fluid communication with said first housing for forcing a predetermined quantity of said fluid out of said dispensing chamber and through said at least one nozzle element, said second housing being detachable from said first housing, and actuation means for exciting said pump means to force said fluid out of said dispensing chamber.

2. The apparatus according to claim 1, wherein said first housing includes a fluid reservoir for holding the quantity of fluid to be dispensed, said fluid reservoir in fluid communication with said dispensing chamber, and a valve assembly for controlling the quantity and rate of transfer of fluid from said fluid reservoir to said dispensing chamber.

3. The apparatus according to claim 1, wherein said at least one of said walls is deformable and adapted to deflect and to modulate the size of said dispensing chamber.

4. The apparatus according to claim 3, wherein said deformable wall comprises a flexible membrane positioned for communication with said pump means.

5. The apparatus according to claim 2, wherein said second housing is adapted for detachable association with said first housing.

6. The apparatus according to claim 1, wherein said first housing is disposable.

7. The apparatus according to claim 1 wherein said apparatus is portable and said actuation means comprises a battery.

8. The apparatus according to claim 1, wherein plural nozzle elements are defined.

9. The apparatus according to claim 1, wherein plural piezoelectric elements are present, and a first piezoelectric element is associated with said dispensing chamber, and a second piezoelectric element is associated with said valve assembly.

10. The apparatus according to claim 1, further including secondary pump means associated with said fluid reservoir to place pressure on said reservoir to expel fluid contained therein.

11. The apparatus according to claim 10, wherein said secondary pump means comprises a spring-biased plunger disposed within said reservoir.

12. A solid state needleless injection system that utilizes piezoelectric materials to forcibly introduce fluid medication through the skin of a patient, said system comprising:

a first housing having at least one wall and defining a dispensing chamber of variable volume formed therein, said dispensing chamber having an output port and an opening formed therein; and

a second housing located in communication with said first housing, said second housing having at least one wall and defining a first piezoelectric actuator, said first piezoelectric actuator being disposed in fluid communication with a wall of said first housing proximate said dispensing chamber, and being excitable so as to provide a driving force against said wall to thereby force fluid from within said dispensing chamber through said output port.

13. The system according to claim 12, wherein said dispensing chamber also has an input port formed therein, wherein said input port allows fluid to enter into said dispensing chamber.

14. The system according to claim 13, further comprising a fluid reservoir, said fluid reservoir having an output port formed therein, said output port of said fluid reservoir being operatively connected to said input port of said dispensing chamber so as to allow said fluid to flow from said fluid reservoir to said dispensing chamber.

15. The system according to claim 14, further comprising a valve assembly operatively connected between said output port of said fluid reservoir and said input port of said dispensing chamber so as to control the flow of fluid between said fluid reservoir to said dispensing chamber.

16. The system according to claim 15, wherein said valve assembly comprises:

a valve seat formed in said first housing;

a valve stop formed in said first housing and positioned to cooperate with said valve seat to alternately permit and prevent the flow of fluid from said fluid reservoir to said dispensing chamber; and

an actuation means for controlling the position of said valve stop with respect to said valve seat.

17. The system according to claim 16, wherein said actuation means comprises a second piezoelectric element, said second piezoelectric element being disposed proximate the wall adjacent said valve stop, and being excitable so as to provide a driving force against said wall and thereby force said valve stop against said valve seat.

18. The system according to claim 17, wherein said second rigid housing having a means for disposing said first piezoelectric actuator proximate said wall and said dispensing chamber and disposing said second piezoelectric actuator proximate said valve stop.

19. The system according to claim 16, wherein said actuation means comprises an electromechanical actuator, said electromechanical actuator being disposed proximate said wall and said dispensing chamber, and being excitable so as to provide a driving force against said wall and thereby force said valve stop against said valve seat.

20. A solid state needleless injection method that utilizes piezoelectric materials to forcibly introduce fluid medication into the skin of a patient, said method comprising the steps of:

providing a first housing, said having a dispensing chamber formed therein, said dispensing chamber having an output port and an opening formed therein;

positioning a first piezoelectric actuator in fluid communication with said first housing and proximate a wall of said first housing; and

exciting said first piezoelectric actuator so as to provide a driving force against said wall and thereby force fluid medication from within said dispensing chamber through said output port.

21. The method according to claim 20, further comprising the steps of:

providing an input port in said dispensing chamber;

connecting a fluid reservoir containing fluid medication to said input port; and

replenishing said dispensing chamber with fluid medication from said fluid reservoir by allowing fluid medication to flow from said fluid reservoir to said dispensing chamber through said input port.

22. The method according to claim 21, further comprising the step of controlling the flow of fluid medication from said fluid reservoir to said dispensing chamber.