Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
First Claim
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1. A dispersion for therapeutic or diagnostic use comprising an aqueous continuous phase suitable for infusion into a human or other animal and dispersed drops comprising a practically immiscible superheated liquid, said drops having an average diameter of 0.05-20 μ
- m, being physically stable in said composition and in said body and having an amount of superheat of at least 17 Celsius degrees, said amount of superheat being sufficient to permit their in-body nucleation by a level of ionizing radiation or ultrasound tolerable to said body.
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Abstract
Dispersions of superheated drops of immiscible liquids in aqueous continuous phase suitable for infusion into a human or other animal, the drops being vaporizable in a selected body location by ionizing radiation or ultrasound. The dispersions can be used to form diagnostic contrast agents, to improve diffusion of drugs, to occlude capillaries and to deliver drugs selectively in a localized body region.
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31 Claims
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1. A dispersion for therapeutic or diagnostic use comprising an aqueous continuous phase suitable for infusion into a human or other animal and dispersed drops comprising a practically immiscible superheated liquid, said drops having an average diameter of 0.05-20 μ
- m, being physically stable in said composition and in said body and having an amount of superheat of at least 17 Celsius degrees, said amount of superheat being sufficient to permit their in-body nucleation by a level of ionizing radiation or ultrasound tolerable to said body.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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