Gastrointestinal drug delivery system
First Claim
1. A drug delivery formulation for localized drug release in the gastrointestinal tract of an animal comprising:
- a. a core comprising a drug and core material; and
b. a coating surrounding said core, said coating having an outer surface,wherein said coating comprises water-insoluble hydrophilic particulate matter embedded in a water-insoluble carrier, such that when said formulation enters the gastrointestinal tract, said particulate matter absorbs liquid, thus forming channels that interconnect said core with said outer surface of said coating, and through which channels, said drug from said core is released into the gastrointestinal tract.
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Accused Products
Abstract
A gastrointestinal delivery system is provided. The system comprises a drug in combination with a core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. These channels allow the release of drug from the core into the gastrointestinal tract. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time- dependent manner.
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Citations
21 Claims
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1. A drug delivery formulation for localized drug release in the gastrointestinal tract of an animal comprising:
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a. a core comprising a drug and core material; and b. a coating surrounding said core, said coating having an outer surface, wherein said coating comprises water-insoluble hydrophilic particulate matter embedded in a water-insoluble carrier, such that when said formulation enters the gastrointestinal tract, said particulate matter absorbs liquid, thus forming channels that interconnect said core with said outer surface of said coating, and through which channels, said drug from said core is released into the gastrointestinal tract. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification