Pain-alleviating drug composition and method for alleviating pain

• US 5,840,731 A
• Filed: 08/02/1995
• Issued: 11/24/1998
• Est. Priority Date: 08/02/1995
• Status: Expired due to Fees

• Current Assignee: Virginia Commonwealth University
• Original Assignee: Virginia Commonwealth University
• Inventors: Lyle, John W., Mayer, David J., Mao, Jianren, Price, Donald D.
• Primary Examiner(s): Spivack, Phyllis G.
• Application Number:
  US08/510,546
• Time in Patent Office: 1,210 Days
• Field of Search: 514/282, 514/289, 514/629
• US Class Current: 514/289
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/515 Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids

Abstract

The analgesic effectiveness of a combination drug composition containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.

Claims

1. A drug composition comprising:

a) a pharmacologically effective amount of an opioid analgesic selected from the group consisting of morphine, heroin, hydromorphone, oxymorphone, levorpbanol, levallorphan, codeine, hydrocodone, oxycodone, nalmefene, nalorphine, naloxone, naltrexone, buprenorphine, butorphanol, nalbuphine, their mixtures and their pharmaceutically acceptable salts;

b) a pharmacologically effective amount of a second component which is the nonopioid analgesic acetaminophen; and

,

c) an analgesia-enhancing amount of a third component which is a nontoxic N-methyl-D-aspartate receptor antagonist selected from the group consisting of dextrorphan, dextromethorphan, their mixtures and their pharmaceutically acceptable salts.

2. A method for alleviating pain which comprises administering to a mammal which is either experiencing pain or is about to be subjected to a pain-causing event a pain-alleviating amount of a drug composition comprising:

a) a pharmacologically effective amount of a first component which is an opioid analgesic selected from the group consisting of morphine, heroin, hydromorphone, oxymorphone, levorphanol levallorphan, codeine, hydrocodone, oxycodone, nalmefene, nalorphine, naloxone, naltrexone, buprenorphine, butorphanol, nalbuphine, their mixtures and their pharmaceutically acceptable salts;

b) a pharmacologically effective amount of a second component which is the nonopioid analgesic acetaminophen; and

,

c) an analgesia-enhancing amount of a third component which is a nontoxic N-methyl-D-aspartate receptor antagonis selected from the group consisting of dextrorphan, dextromethorphan, their mixtures and their pharmaceutically acceptable salts.

3. The method of claim 2 wherein the pain is arthritic pain, lumbosacral pain, musculoskeletal pain, post-operative pain or headache.