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Process for aligning, adhering and stretching nucleic acid strands on a support surface by passage through a meniscus

  • US 5,840,862 A
  • Filed: 06/06/1995
  • Issued: 11/24/1998
  • Est. Priority Date: 02/11/1994
  • Status: Expired due to Term
First Claim
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1. A process for aligning a nucleic acid strand on a surface, wherein the process comprises:

  • (a) providing a solvent for the nucleic acid strand between two surfaces where one surface is an anchoring surface to which one end of the nucleic acid strand is anchored by a bond and another end of the nucleic acid strand is free, and where the solvent forms a meniscus between and perpendicular to the surfaces at an interface of the solvent with air between the surfaces; and

    (b) moving the meniscus and solvent between the surfaces so that the nucleic acid strand passes through the meniscus into air at the interface whereby the nucleic acid strand is aligned on the anchoring surface perpendicular to the meniscus without breaking the bond that anchors the end of the nucleic acid strand to the surface.

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