Apparatus and method for integrated sampling from closed and open sample containers

• US 5,841,039 A
• Filed: 12/09/1992
• Issued: 11/24/1998
• Est. Priority Date: 04/04/1991
• Status: Expired due to Term

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Technicon Instruments Corporation (Bayer AG)
• Inventors: Uffenheimer, Kenneth F.
• Primary Examiner(s): RAEVIS, ROBERT R
• Application Number:
  US07/988,074
• Time in Patent Office: 2,176 Days
• Field of Search: 73/864.21-864.25, 73/864.83, 73/864.84, 73/864.87, 73/864.01, 73/864.11-864.18, 73/864.24, 422/100, 422/104, 422/63, 422/81
• US Class Current: 73/864.24
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers thereon on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierced stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe. Air segmented rinse liquid is provided for the sampling needle, transfer conduits, transfer valve, and dispensing well to minimize sample liquid carryover with regard to the sample liquids from the closed containers; and a surfactant is included with the rinse to lubricate the sampling needle to facilitate the piercing thereby of the closed sample liquid container stoppers and minimize the generation of sample liquid-contaminating stopper particles to use with aqueous sample and rinse liquids, hydrophobic sample liquid transfer conduits, transfer valve, and dispensing well surfaces are provided; and an isolation liquid which selectively wets those surfaces to the substantial exclusion of the aqueous sample and rinse liquids, is utilized in conjunction with the rinse liquid to further minimize sample liquid carryover. The open sample liquid containers and the dispensing well are supported at essentially the same level relative to the probe to maximize sampling accuracy thereby. A detector is provided to detect sample liquid identification as supported from the sample liquid container support component, and to differentiate between open and closed sample liquid containers for operation of the sample liquid analysis system probe in accordance therewith.

Claims

1. In sample liquid container support apparatus for use in a sampler, the improvements comprising, said support apparatus comprising, a plurality of sample liquid container mounting means each of which is operable to mount either a closed sample liquid container or an open sample liquid container, and means on said support apparatus for operatively connecting said support apparatus to a sampler for use in said sampler.

2. In sample liquid container support apparatus as in claim 1, the improvements further comprising, each of said sample liquid container mounting means forming a sample liquid container mounting aperture for the mounting of a sample liquid container therein.

3. In sample liquid container support apparatus as in claim 2, the improvements further comprising, said sample liquid container mounting apertures being generally vertically oriented, with each of said apertures being adapted to mount a closed sample liquid container therein with the closed container end down, or an open sample liquid container therein with the open container end up.

4. In sample liquid container support apparatus as in claim 2, the improvements further comprising, closed sample liquid container retaining means operatively associated with said sample liquid container mounting apertures and operable to retain closed sample liquid containers therein.

5. In sample liquid container support apparatus as in claim 1, the improvements further comprising, said sample liquid container mounting means comprising means for mounting said open sample liquid containers at essentially the same level relative to said support means.

6. In a method for integrated sample liquid containers for use in a sampler, the improvements comprising, the steps of, providing a plurality of sample liquid container mounting means on the same sample liquid container support means, and mounting both closed sample liquid containers and open sample liquid containers on said same sample liquid container support means to said integrated sampler.

7. In a method as in claim 6, the improvements further comprising, the steps of, mounting closed sample liquid containers and open sample liquid containers on a random basis on said same sample liquid container support means.

8. In a method as in claim 6, the improvements further comprising, the steps of mounting said closed sample liquid containers on said sample liquid container support means comprising the generally vertical mounting of the same thereon with the closed sample liquid container end down.

9. In a method as in claim 6, the improvements further comprising, the steps of, retaining said closed sample liquid containers mounted on said sample liquid container support means.