Local polymeric gel cellular therapy
First Claim
1. A method for altering cellular interactions on a surface, the method comprising applying a biocompatible polymeric material to a cellular or tissue surface, wherein the polymeric material is applied in a first fluent state and converted in situ to a second non-fluent state, and wherein the material in the second non-fluent state has a controlled porosity and permeability for passage therethrough of macromolecules, microorganisms, and cells, wherein the polymeric material has incorporated therein a bioactive agent which is a modulator of cellular interactions.
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Accused Products
Abstract
A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen, which alter cell to cell interactions.
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Citations
19 Claims
- 1. A method for altering cellular interactions on a surface, the method comprising applying a biocompatible polymeric material to a cellular or tissue surface, wherein the polymeric material is applied in a first fluent state and converted in situ to a second non-fluent state, and wherein the material in the second non-fluent state has a controlled porosity and permeability for passage therethrough of macromolecules, microorganisms, and cells, wherein the polymeric material has incorporated therein a bioactive agent which is a modulator of cellular interactions.
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7. A method for altering cellular interactions, the method comprising applying a polymeric material to a substrate selected from the group consisting of a prosthesis, implant, and unstable plaque;
- wherein the polymeric material is applied in a first fluent state and converted in situ to a second non-fluent state; and
wherein the material in the second non-fluent state has a controlled porosity and permeability for passage therethrough of macromolecules, microorganisms, and cells; and
wherein the polymeric material has incorporated therein a bioactive agent which is a modulator of cellular interactions. - View Dependent Claims (8)
- wherein the polymeric material is applied in a first fluent state and converted in situ to a second non-fluent state; and
Specification