Keratoprosthesis and method of corneal replacement

• US 5,843,185 A
• Filed: 10/23/1996
• Issued: 12/01/1998
• Est. Priority Date: 10/23/1996
• Status: Expired due to Fees

• Current Assignee: Carlos R. Leon Rolden, Jose I. Barraquer Granados
• Original Assignee: Carlos R. Leon Rolden, Jose I. Barraquer Granados
• Inventors: Leon Rolden, Carlos R., Barraquer Granados, Jose I.
• Primary Examiner(s): Milano, Michael J.
• Assistant Examiner(s): NGUYEN, TRAM A
• Application Number:
  US08/740,005
• Time in Patent Office: 769 Days
• Field of Search: 623/4-6
• US Class Current: 623/5.11
• CPC Class Codes: A61F 2/142 Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24

Abstract

An improved keratoprosthesis, to be utilized to enhance a patient'"'"'s vision, which includes an optical support segment structured to be disposed on an eyeball of the patient and containing an optical aperture, structured to be disposed in aligned, overlying relation to a corneal region of the eyeball of the patient, defined therein. Further, the optical support segment includes a disc like configuration and is constructed of hydroxyapatite which is structured and disposed to promote cell growth, increased vascularization and/or bone formation therein so as to substantially increase the optical support segment'"'"'s long term assimilation with the eyeball of the patient, as well as its ability to combat infection and heal quickly. Disposed in the optical aperture of the optical support segment and effectively suspended in a vision enhancing position is an optical cylinder. The optical cylinder is preferably removable and provides for the transmittal of light into the eyeball.

Claims

1. To be utilized to enhance a patient'"'"'s vision, an improved keratoprosthesis comprising:

an optical support segment, said optical support segment being structured to be disposed in assimilating engagement with an ocular musculature of on a living eyeball of the patient,

an optical aperture defined in said optical support segment and structured to be disposed in aligned, relation to a cornea of the eyeball of the patient,

an optical cylinder disposed in said optical aperture, and

said optical support segment is constructed at least partially of hydroxyapatite structured and disposed to promote cell growth and vascularization therein so as to substantially increase said optical support segment'"'"'s long term assimilation with the eyeball of the patient.

2. An improved keratoprosthesis as recited in claim 1 further including a protein layer disposed on said optical support segment and structured to promote bone growth and assimilation.

3. An improved keratoprosthesis as recited in claim 2 wherein said protein layer includes bone morphogenic protein.

4. An improved keratoprosthesis as recited in claim 3 wherein said bone morphogenic protein is absorbed and stored by said hydroxyapatite for subsequent controlled timed release thereby to initiate cell growth and bone formation.

5. An improved keratoprosthesis as recited in claim 1 further including a growth factor substance disposed on said optical support segment and structured to promote assimilation.

6. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite includes porous hydroxyapatite.

7. An improved keratoprosthesis as recited in claim 6 wherein said porous hydroxyapatite includes a plurality of pores defined therein and having diameters of between approximately 10 microns and 400 microns.

8. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite includes granular hydroxyapatite.

9. An improved keratoprosthesis as recited in claim 1 wherein said optical support segment further includes a synthetic reinforcement layer structured to provide said optical support segment with added strength.

10. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite is aragonite based.

11. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite is calcite based.

12. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite includes a dense hydroxyapatite matrix.

13. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite includes at least one low density hydroxyapatite sheet.

14. An improved keratoprosthesis as recited in claim 1 wherein said hydroxyapatite includes natural mammalian bone hydroxyapatite.

15. An improved keratoprosthesis as recited in claim 1 wherein said optical cylinder includes a flange element structured to be secured with said optical support segment.

16. An improved keratoprosthesis as recited in claim 1 wherein said optical support segment includes a generally disk-like configuration.

17. An improved keratoprosthesis as recited in claim 16 wherein said optical support segment includes a diameter of about between 5 mm and 15 mm.

18. An improved keratoprosthesis as recited in claim 1 wherein said optical aperture includes a diameter of about between 1 mm and 10 mm.

19. An improved keratoprosthesis as recited in claim 1 wherein a perimeter of said optical support segment includes a narrowing taper so as to provide a more uniform transition between said optical support segment and the eyeball.

20. An improved keratoprosthesis as recited in claim 1 wherein said optical support segment includes a concave lower surface.

21. An improved keratoprosthesis as recited in claim 1 wherein a lower surface of said optical support segment is structured to correspond a surface configuration of the eyeball.

22. To be utilized to enhance a patient'"'"'s vision, an improved keratoprosthesis comprising:

an optical support segment, said optical support segment being structured to be disposed in assimilating engagement with an ocular musculature of the eyeball of the patient,

an optical aperture defined in said optical support segment and structured to be disposed in aligned, relation to a cornea of the eyeball of the patient,

an optical cylinder disposed in said optical aperture,

said optical support segment is constructed at least partially of hydroxyapatite structured and disposed to promote cell growth and vascularization therein so as to substantially increase said optical support segment'"'"'s long term assimilation with the eyeball of the patient, and

said optical support segment further including a synthetic reinforcement layer integrally disposed therewith and structured to provide said optical support segment with added strength.