Method of treatment of infected tissues
First Claim
1. A method of treating a systemic infection which is localized at a site other than the fixed macrophages residing in the liver or the spleen, comprisingadministering to the subject, by intravenous injection, a composition of liposomes (i) composed of vesicle-forming lipids, including 1-35 mole percent of a diacyl-chain amphipathic vesicle-forming lipid derivatized with polyethylene glycol having a molecular weight between about 350 and 5,000 daltons (ii) having a selected mean particle diameter in the size range between about 0.07-0.20 microns, and (iii) containing in liposome-entrapped form, a therapeutic compound effective against the source of the infection, andby said injecting, achieving at least about a ten-fold increase in the concentration of liposomes in the infected tissue over that achievable by the such liposomes in the absence of the amphipathic vesicle-forming lipid derivatized with said polyethylene glycol.
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Abstract
A method of treating a site of systemic infection which includes administering a therapeutic compound entrapped in liposomes. Also included is a liposomal composition and a method of preparing a liposomal composition for use in concentrating a therapeutic compound to an infected region via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids, a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer, and have sizes in a selected size range between 0.07 and 0.2 microns. After parenteral administration, the liposomes are selectively taken up by the infected region within 24-48 hours, for release of entrapped compound into the infected region.
103 Citations
5 Claims
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1. A method of treating a systemic infection which is localized at a site other than the fixed macrophages residing in the liver or the spleen, comprising
administering to the subject, by intravenous injection, a composition of liposomes (i) composed of vesicle-forming lipids, including 1-35 mole percent of a diacyl-chain amphipathic vesicle-forming lipid derivatized with polyethylene glycol having a molecular weight between about 350 and 5,000 daltons (ii) having a selected mean particle diameter in the size range between about 0.07-0.20 microns, and (iii) containing in liposome-entrapped form, a therapeutic compound effective against the source of the infection, and by said injecting, achieving at least about a ten-fold increase in the concentration of liposomes in the infected tissue over that achievable by the such liposomes in the absence of the amphipathic vesicle-forming lipid derivatized with said polyethylene glycol.
Specification