Lubricants for use in tabletting

• US 5,843,477 A
• Filed: 09/30/1997
• Issued: 12/01/1998
• Est. Priority Date: 09/30/1997
• Status: Expired due to Term

• Current Assignee: Bayer Corporation (Bayer AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Alexander, Thomas A.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Seidleck, Brian K.
• Application Number:
  US08/941,086
• Time in Patent Office: 427 Days
• Field of Search: 424/464, 424/465, 424/466, 424/489
• US Class Current: 424/466
• CPC Class Codes: A61K 9/0007 Effervescent A61K9/0065 takes precedence
• CPC Class Codes: A61K 9/2013 Organic compounds, e.g. phospholipids, fats

Abstract

The invention provides a new water soluble lubricant combination which facilitates the production of tablets. The combination of glyceryl behenate and fumaric acid is useful as a lubricant, particularly in tablet compositions containing ingredients where rapid dissolution in an aqueous environment is desired for activity or desired for aesthetic purposes. This lubricant combination has fewer limitations and improved functionality in comparison to standard lubricants presently known. In addition, the lubricants provided may be used with known hydrophobic lubricants to decrease the amount of the hydrophobic lubricant required for lubrication.

Claims

1. A method of preparing a tablet, comprising the steps of:

a. preparing the lubricant combination of glyceryl behenate and micronized fumaric acid;

b. adding the lubricant combination and the desired tablet ingredients to a mixer;

c. blending the contents of the mixer;

d. compressing the blended contents to produce a tablet.

2. The method of claim 1, wherein said glyceryl behenate is present in the amount of about 0.15% to 0.35% per tablet.

3. The method of claim 1, wherein said micronized fumaric acid is present in the amount of about 1.0% to 2.0% per tablet.

4. The method of claim 1, wherein said tablet is effervescent.

5. A tablet prepared by the method according to claim 1.

6. The tablet of claim 5, wherein said glyceryl behenate is present in an amount of about 0.15% to 0.35% per tablet.

7. The tablet of claim 5, wherein said micronized fumaric acid is present in an amount of about 1.0% to 2.0% per tablet.

8. The tablet of claim 5, wherein said tablet is effervescent.