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Cleavage of nucleic acid acid using thermostable methoanococcus jannaschii FEN-1 endonucleases

  • US 5,843,669 A
  • Filed: 11/29/1996
  • Issued: 12/01/1998
  • Est. Priority Date: 01/24/1996
  • Status: Expired due to Term
First Claim
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1. A mixture comprising a first structure-specific nuclease, said first nuclease consisting of the Mja FEN-1 endonuclease and a second structure-specific nuclease, wherein said second nuclease is a 5'"'"' nuclease derived from a thermostable DNA polymerase altered in amino acid sequence such that it exhibits reduced DNA synthetic activity from that of the wild-type DNA polymerase but retains substantially the same 5'"'"' nuclease activity of the wild-type DNA polymerase.

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