Vaccines against animal parasitic nematodes
First Claim
1. An isolated and purified DNA molecule encoding a parasitic nematode tropomyosin protein capable of conferring protective immunity against infection of a host by a parasitic nematode species, wherein said tropomyosin protein binds to antibodies raised against a protein isolated from Trichostrongylus colubriformis,wherein said Trichostrongylus colubriformis protein has an approximate molecular weight of 41 kD as determined by SDS-PAGE, and comprises the amino acid sequence:
- ##STR83##
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Abstract
The invention disclosed relates to proteins derived from parasitic nematodes that confer protective immunity against infection by parasitic nematodes, to nucleotide sequences encoding those proteins, to recombinant molecules containing such sequences, to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences, recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.
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Citations
26 Claims
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1. An isolated and purified DNA molecule encoding a parasitic nematode tropomyosin protein capable of conferring protective immunity against infection of a host by a parasitic nematode species, wherein said tropomyosin protein binds to antibodies raised against a protein isolated from Trichostrongylus colubriformis,
wherein said Trichostrongylus colubriformis protein has an approximate molecular weight of 41 kD as determined by SDS-PAGE, and comprises the amino acid sequence:
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17. An isolated and purified DNA molecule comprising the sequence:
- ##STR86##
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18. An isolated and purified DNA molecule comprising the sequence:
- ##STR87##
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19. An isolated and purified DNA molecule comprising the sequence:
- ##STR88##
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20. An isolated and purified DNA molecule comprising the sequence:
- ##STR89##
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21. An isolated and purified DNA molecule comprising the sequence:
- ##STR90##
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22. Plasmid pBTA593.
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23. Plasmid pBTA597.
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24. Plasmid pBTA598.
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25. Plasmid pBTA702.
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26. Plasmid pBTA704.
Specification