Gels for encapsulation of biological materials
First Claim
1. A substrate comprising a surface having a polymeric coating thereon formed by free radical polymerization of a biocompatible, water soluble macromer having covalently linked to it at least two free radical polymerizable substituents,wherein the coating is formed on the substrate surface by:
- a) contacting the surface with a solution of a free radical polymerization initiator;
b) applying to the surface a biocompatible, water-soluble macromer comprising at least two free radical polymerizable substituents; and
c) exposing the surface to an agent to activate the initiator to cause the polymerization of the macromers to form the polymeric coating on the surface.
1 Assignment
0 Petitions
Accused Products
Abstract
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
155 Citations
22 Claims
-
1. A substrate comprising a surface having a polymeric coating thereon formed by free radical polymerization of a biocompatible, water soluble macromer having covalently linked to it at least two free radical polymerizable substituents,
wherein the coating is formed on the substrate surface by: -
a) contacting the surface with a solution of a free radical polymerization initiator; b) applying to the surface a biocompatible, water-soluble macromer comprising at least two free radical polymerizable substituents; and c) exposing the surface to an agent to activate the initiator to cause the polymerization of the macromers to form the polymeric coating on the surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
Specification