Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity
First Claim
1. A method for inducing immunological tolerance in a subject to a skin sensitizing drug or agent administered to the skin, which method comprises administering to said subject prior to, at the onset of, or both prior to and at the onset of, dermal or transdermal delivery of said sensitizing drug or agent, an effective amount of at least one mast cell degranulating agent.
0 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions for inhibiting or preventing the skin irritating or sensitizing effects of a skin irritating or sensitizing component of a dermal or transdermal drug delivery system are disclosed. The composition comprises a mast cell degranulating agent which is capable of inducing a state of immunological tolerance to the skin sensitizing agent by delivery prior to, or at the onset of transdermal drug delivery. Such an agent, preferably cis-urocanic acid or an analogue or metabolite thereof, can be administered before, during or after each transdermal drug delivery to achieve immune tolerance countersensitization. Alternatively, the agent can be used to induce countersensitization. The agent is preferably capable of permeating the epidermis and is administered transdermally. Novel methods and compositions comprising cis-urocanic acid or an analogue or metabolite thereof to obtain anti-inflammatory effects are also disclosed.
-
Citations
31 Claims
- 1. A method for inducing immunological tolerance in a subject to a skin sensitizing drug or agent administered to the skin, which method comprises administering to said subject prior to, at the onset of, or both prior to and at the onset of, dermal or transdermal delivery of said sensitizing drug or agent, an effective amount of at least one mast cell degranulating agent.
-
7. A method for preventing or inhibiting the skin irritating or skin sensitizing effect of a drug administered to the skin, which method comprises administering before, together with, before and together with, or after said drug, an effective amount of at least one mast cell degranulating agent.
- 8. A method for preventing or inhibiting the skin irritating or skin sensitizing effect of a component of a dermal or transdermal drug delivery system, which method comprises administering before, together with, before and together with, or after said component, an effective amount of at least one mast cell degranulating agent.
-
18. An article useful for preventing or inhibiting the skin irritating or skin sensitizing effect of a component of a dermal or transdermal drug delivery system, said article comprising:
-
(a) a dermal or transdermal delivery system comprising a therapeutic drug of interest; and (b) an effective amount of at least one mast cell degranulating agent. - View Dependent Claims (19, 20, 21, 22, 23, 24)
-
-
25. A pharmaceutical composition useful for preventing or inhibiting the skin irritating or skin sensitizing effect of a component of a dermal or transdermal drug delivery system, said composition comprising:
an amount of at least one mast cell degranulating agent effective to prevent or inhibit the skin irritating or skin sensitizing effect of a component of a dermal or transdermal drug delivery system and an acceptable pharmaceutical carrier. - View Dependent Claims (26, 27, 28, 29)
- 30. A method for inhibiting an inflammatory reaction in the skin of a subject associated with a skin sensitizing reaction, which method comprises administering to said subject an effective amount of at least one mast cell degranulating agent.
Specification