Human TRK receptors and neurotrophic factor inhibitors
First Claim
Patent Images
1. A chimeric polypeptide comprising an immunoglobulin constant domain sequence fused to a neurotrophin-binding polypeptide sequence comprising a second immunoglobulin-like domain sequence of human trkA, human trkB, or human trkC, wherein the chimeric polypeptide binds a neurotrophin that binds human trkA, human trkB, or human trkC.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
-
Citations
19 Claims
- 1. A chimeric polypeptide comprising an immunoglobulin constant domain sequence fused to a neurotrophin-binding polypeptide sequence comprising a second immunoglobulin-like domain sequence of human trkA, human trkB, or human trkC, wherein the chimeric polypeptide binds a neurotrophin that binds human trkA, human trkB, or human trkC.
Specification