Hollow frustum reagent test device

• US 5,846,486 A
• Filed: 08/09/1996
• Issued: 12/08/1998
• Est. Priority Date: 08/09/1996
• Status: Expired due to Term

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Pugh, Jerry Thomas
• Primary Examiner(s): SNAY, JEFFREY R
• Application Number:
  US08/694,960
• Time in Patent Office: 851 Days
• Field of Search: 422/55, 422/56, 422/57, 422/58, 422/99, 422/100, 422/101, 422/82.05
• US Class Current: 422/408
• CPC Class Codes: B01L 3/0275 Interchangeable or disposable dispensing tips
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: G01N 2035/1055 for immobilising reagents, e.g. dried reagents
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 33/528 Atypical element structures, e.g. gloves, rods, tampons, toilet paper

Abstract

A hollow, frustum-shaped disposable device is used in an apparatus for measuring the concentration of an analyte in a sample of a biological fluid. The smaller end of the frustum has a porous membrane, to which a sample of the fluid may be applied. Preferably, a reagent in the membrane reacts with the analyte to cause a color change. The device is mounted on a meter, which measures the color change and computes from the change the analyte concentration in the sample. The apparatus permits remote dosing of the device, which minimizes the likelihood of cross-contamination between the user and the meter. Devices can be mounted on the meter and released from the meter without touching them, to further protect against contamination.

Claims

1. A device for use in an apparatus for measuring a concentration of an analyte in a sample of a biological fluid, comprising

(a) a hollow frustum, having open ends of unequal size, the smaller open end having an inward-extending lip, and

(b) a porous membrane for accepting the sample, attached to raised portions of a surface of the lip and substantially closing the smaller open end, the membrane comprising

(i) a first surface for accepting the sample and

(ii) a reagent for reacting with the analyte to cause a color change at a second surface, opposite to the first surface, resulting in a change in reflectance at the second surface that can be measured and be related to the concentration of the analyte in the sample.

2. The device of claim 1, in which the frustum has a rectangular cross section.

3. The device of claim 1 in which the frustum has a circular cross section.

4. The device of claim 1 in which the membrane comprises polyamide.

5. The device of claim 1 in which the membrane comprises polysulfone.

6. The device of claim 1 in which the frustum has a plurality of circumferential indentations.

7. The device of claim 1 further comprising an absorbent pad over the first surface of the membrane.

8. The device of claim 1 in which the larger open end has an outward-extending flange.