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System to detect small molecule/peptide interaction

  • US 5,846,722 A
  • Filed: 10/16/1996
  • Issued: 12/08/1998
  • Est. Priority Date: 10/16/1996
  • Status: Expired due to Fees
First Claim
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1. A method to determine whether an agent and a target protein interact, said method comprising the steps of:

  • contacting an agent/ligand complex comprising a small molecule agent to be tested for binding to a target protein coupled to a ligand that binds a proteinaceous ligand-binding domain witha first fusion protein comprising said target protein and a first complementary portion of a segregable protein; and

    a second fusion protein comprising a proteinaceous ligand-binding domain and a second complementary portion of said segregable protein; and

    detecting whether the first complementary portion and second complementary portion are brought into proximity.

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