×

Polyphoshoinositide binding peptides for intracellular drug delivery

  • US 5,846,743 A
  • Filed: 11/22/1996
  • Issued: 12/08/1998
  • Est. Priority Date: 02/22/1995
  • Status: Expired due to Fees
First Claim
Patent Images

1. A compound comprising:

  • (i) a carrier molecule for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across a membrane of a cell, the carrier molecule having the formula;

    
    
    space="preserve" listing-type="equation">X-P,whereinP is a transport-mediating peptide selected from the group consisting of Seq. I.D. Nos. 1-35 and 36; and

    X is a terminal amine derivatizing agent that is covalently coupled to the N-terminus amine of the transport-mediating peptide,wherein each of the functionally equivalent peptides is a basic polyphosphoinositide binding peptide containing between three and ten amino acids, and(ii) a membrane-impermeable extracellular agent, A, covalently coupled to the carboxyl terminus of the transport-mediating peptide to form a prodrug having the formula, X-P-A.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×