Process for the preparation of D-arabitol

• US 5,846,794 A
• Filed: 05/27/1997
• Issued: 12/08/1998
• Est. Priority Date: 05/29/1996
• Status: Expired due to Fees

• Current Assignee: Roquette Freres
• Original Assignee: Roquette Freres
• Inventors: Delobeau, Didier, Moine, Didier
• Primary Examiner(s): PRATS, FRANCISCO CHANDLER
• Application Number:
  US08/863,579
• Time in Patent Office: 560 Days
• Field of Search: 536/1.11, 536/124, 568/852, 568/863, 435/105, 435/158, 435/155
• US Class Current: 435/158
• CPC Class Codes: C07C 29/141 with hydrogen or hydrogen-containing gases
• CPC Class Codes: C07C 31/18 Polyhydroxylic acyclic alcohols
• CPC Class Codes: C07C 51/313 with molecular oxygen
• CPC Class Codes: C07C 59/105 having five or more carbon atoms, e.g. aldonic acids
• CPC Class Codes: C07H 3/02 Monosaccharides
• CPC Class Codes: C12P 19/14 produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase , e.g. by cellulase, hemicellulase
• CPC Class Codes: C12P 7/58 Aldonic, ketoaldonic or saccharic acids uronic acids C12P19/00
• CPC Class Codes: C13K 13/00 Sugars not otherwise provided for in this class

Abstract

A process for the preparation of D-arabitol, characterised in that it comprises the following stages:

hydrolysis of a lactose solution,

oxidation of the mixture of glucose and galactose thus obtained to a mixture of gluconic and galactonic acids,

decarboxylation of this mixture of gluconic and galactonic acids to a mixture of D-arabinose and D-lyxose,

catalytic hydrogenation of this mixture of D-arabinose and D-lyxose to D-arabitol.

Claims

1. A process for the preparation of D-arabitol, wherein it comprises the following stages:

hydrolysis of a lactose solution,

oxidation of the mixture of glucose and galactose thus obtained to a mixture of gluconic and galactonic acids,

decarboxylation of this mixture of gluconic and galactonic acids to a mixture of D-arabinose and D-lyxose,

catalytic hydrogenation of this mixture of D-arabinose and D-lyxose to D-arabitol.

2. A process for the preparation of D-arabitol according to claim 1, wherein the hydrolysis of the lactose solution is carried out by chemical means.

3. A process for the preparation of D-arabitol according to claim 1, wherein the hydrolysis of the lactose solution is carried out with enzymes.

4. A process for the preparation of D-arabitol according to claim 1, wherein the oxidation of the mixture of glucose and galactose is carried out in the presence of air or oxygen, in an alkaline medium and in the presence of palladium catalysts.

5. A process for the preparation of D-arabitol according to claim 1, wherein the oxidation of the mixture of glucose and galactose is carried out by microbial means using microorganisms.

6. A process for the production of D-arabitol according to claim 1, wherein the gluconic and galactonic acids are in the form of calcium salts.

7. A process for the production of D-arabitol according to claim 1, wherein the decarboxylation of the mixture of gluconic and galactonic acids is carried out using hydrogen peroxide.

8. A process for the production of D-arabitol according to claim 1, wherein the catalytic hydrogenation of the mixture of D-arabinose and D-lyxose is carried out using RANEY nickel.

9. A process for the preparation of D-arabitol according to claim 5, wherein said microorganisms comprise Gluconobacter oxydans.