Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
First Claim
1. A method for treating a cardiovascular disease mediated by VCAM-1 expression in humans, comprising administering an effective amount of a substance which inhibits the oxidation of a polyunsaturated fatty acid (PUFA) in combination with another cardiovascular drug selected from the group consisting of lipid lowering agents, platelet aggregation inhibitors, antithrombotic agents, calcium channel blockers, angiotensin converting enzyme (ACS) inhibitors, and β
- -blockers.
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Abstract
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
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Citations
37 Claims
- 1. A method for treating a cardiovascular disease mediated by VCAM-1 expression in humans, comprising administering an effective amount of a substance which inhibits the oxidation of a polyunsaturated fatty acid (PUFA) in combination with another cardiovascular drug selected from the group consisting of lipid lowering agents, platelet aggregation inhibitors, antithrombotic agents, calcium channel blockers, angiotensin converting enzyme (ACS) inhibitors, and β
- 2. A method for treating an inflammatory disease mediated by VCAM-1 expression in humans, comprising administering an effective amount of a substance which inhibits the oxidation of a polyunsaturated fatty acid (PUFA) in combination with another antiinflammatory drug.
- 21. A method for treating a disease mediated by VCAM-1 comprising administering an effective amount of a substance that prevents or minimizes the oxidation of a polyunsaturated fatty acid.
Specification