Fatty acid derivatives

• US 5,847,000 A
• Filed: 03/28/1997
• Issued: 12/08/1998
• Est. Priority Date: 03/01/1994
• Status: Expired due to Fees

• Current Assignee: Scarista Limited (FSD Pharma, Inc.)
• Original Assignee: Scotia Holdings Plc
• Inventors: Knowles, Philip, Horrobin, David F., Manku, Mehar S
• Primary Examiner(s): Harrison, Robert H.
• Application Number:
  US08/828,716
• Time in Patent Office: 620 Days
• Field of Search: 514/310, 514/474, 514/552, 514/546, 514/943, 514/960, 514/962, 549/315, 424/451, 424/464
• US Class Current: 514/552
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1874 Linolenic acid
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C07D 307/62 Three oxygen atoms, e.g. ascorbic acid

Abstract

Ascorbyl-GLA or Ascorbyl-DGLA in medicaments for treatment of asthma and other disorders.

Claims

1. An orally adminstrable tablet or capsule consisting essentially of the ascorbic-6-acid ester of gamma-linolenic acid or the ascorbic-6-acid ester of dihomo-gamma-linolenic acid in association with a pharmaceutically acceptable carrier or diluent.

2. The tablet or capsule of claim 1 containing 0.001% to 50% by weight of the ester.

3. The tablet or capsule of claim 1 containing 0.1% to 20% by weight of the ester.

4. The tablet or capsule of claim 1 containing 1% to 10% by weight of the ester.

5. The tablet or capsule of claim 1 including an oil which contains at least 5% by weight of gamma-linolenic acid, dihomo-gamma-linolenic acid or an essential fatty acid in the free fatty acid form or triglyceride form.

7. The tablet/capsule/parenteral composition of claim 1 or 6 further including gamma-linolenic acid or dihomo-gamma-linolenic acid in free fatty acid or triglyceride form.

10. The composition of claim 1 including an oil which contains at least 1% to 10% by weight of the ester.

6. A parenteral composition consisting essentially of the ascorbic-6-acid ester of gamma-linolenic acid or the ascorbic-6-acid ester of dihomo-gamma-linolenic acid in association with a pharmaceutically acceptable carrier or diluent.

8. The composition of claim 6 containing 0.001% to 50% by weight of the ester.

9. The composition of claim 6 containing 0.1% to 20% by weight of the ester.

11. The composition of claim 6 further including an oil which contains at least 5% by weight of gamma-linolenic acid, dihomo-gamma-linolenic acid or an essential fatty acid in the free fatty acid form or triglyceride form.