Method for treating neuronal diseases via administration of 2-acylaminopropanol derivatives

• US 5,849,326 A
• Filed: 06/06/1995
• Issued: 12/15/1998
• Est. Priority Date: 08/13/1993
• Status: Expired due to Term

• Current Assignee: Seikagaku Corporation
• Original Assignee: Seikagaku Corporation
• Inventors: Usuki, Seigou, Yamada, Haruki, Inokuchi, Jinichi, Muramoto, Kazuyo, Kuroda, Yoichiro
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US08/466,243
• Time in Patent Office: 1,288 Days
• Field of Search: 424/450, 424/451, 424/464, 424/489, 424/45, 514/938, 514/237.8, 514/937
• US Class Current: 424/450
• CPC Class Codes: A61K 31/5375 1,4-Oxazines, e.g. morpholine
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 295/125 with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
• CPC Class Codes: C07D 295/13 to an acyclic saturated chain

Abstract

Disclosed is an agent for curing neuronal diseases caused by disorders of peripheral nervous system or central nervous system, which comprises a 2-acylaminopropanol compound of the formula: ##STR1## wherein R¹ represents a phenyl group or cyclohexyl group each of which may be substituted by 1 to 3 same or different substituents selected from the group consisting of alkyl, alkoxy, hydroxy and nitro, or represents an alkyl group, and n represents an integer of 0 to 16,

or a pharmaceutically acceptable salt thereof as an effective ingredient.

Claims

1. A method of treating neuronal diseases in warm-blooded animals which comprises administering to warm-blooded animals an amount of a 2-acylaminopropanol of the formula ##STR4## wherein R¹ is phenyl or cyclohexyl, each of which may be substituted by 1 to 3 same or different substituents selected from the group consisting of alkyl, alkoxy, hydroxy and nitro, or wherein R¹ is alkyl, and n is an integer of 0 to 16 or a pharmaceutically acceptable salt thereof effective for effecting an activity selected from the group consisting of accelerating biosynthesis of glucosphingolipids, accelerating neurite extension and accelerating synapse formation in warm-blooded animals which suffer from neuronal diseases.

2. The method of treating neuronal diseases according to claim 1, wherein n of the formula (I) is 6 to 16.

3. The method of treating neuronal diseases according to claim 1, wherein R¹ of the formula (I) is a phenyl group.

4. The method of treating neuronal diseases according to claim 1, wherein the 2-acylaminopropanol represented by the formula (I) is a L-threo isomer.

5. The method of treating neuronal diseases according to claim 4, wherein the 2-acylaminopropanol is a L-threo isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, or a salt thereof.

6. The method of claim 1 wherein the daily amount of the compound of Formula I is 0.25 to 200 mg/kg.