Intralumenal drug eluting prosthesis
First Claim
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1. A device for local intralumenal administration of drugs comprising:
- (a) a catheter having proximal and distal ends;
(b) a first body in the form of an open-ended, radially expandable, self-supporting tubular structure, said first tubular body mounted on the catheter at the distal end thereof;
(c) a second body having a polymer with a drug compounded therein, the second body in the form of an open-ended, radially expandable tubular structure having an interior surface and an exterior surface, at least a portion of the polymer exposed at the exterior surface thereof, said second tubular body mounted on the catheter at the distal end thereof;
(d) means at the proximal end of the catheter for radially expanding the first and second tubular bodies to bring the self-supporting structure of the first tubular body into coaxial supporting contact with the interior surface of the second tubular body such that the polymer exposed at the exterior surface of the second tubular body contacts an interior portion of the body lumen to be treated.
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Abstract
A prosthesis for insertion into a lumen to limit restenosis of the lumen. The prosthesis carries restenosis-limiting drugs which elute after the device is positioned in the lumen.
221 Citations
73 Claims
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1. A device for local intralumenal administration of drugs comprising:
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(a) a catheter having proximal and distal ends; (b) a first body in the form of an open-ended, radially expandable, self-supporting tubular structure, said first tubular body mounted on the catheter at the distal end thereof; (c) a second body having a polymer with a drug compounded therein, the second body in the form of an open-ended, radially expandable tubular structure having an interior surface and an exterior surface, at least a portion of the polymer exposed at the exterior surface thereof, said second tubular body mounted on the catheter at the distal end thereof; (d) means at the proximal end of the catheter for radially expanding the first and second tubular bodies to bring the self-supporting structure of the first tubular body into coaxial supporting contact with the interior surface of the second tubular body such that the polymer exposed at the exterior surface of the second tubular body contacts an interior portion of the body lumen to be treated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 68, 69)
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25. A device for local intralumenal administration of drugs comprising:
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(a) a catheter having proximal and distal ends; (b) a first body in the form of an open-ended, radially expandable, self-supporting tubular structure, said first tubular body mounted on the catheter at the distal end thereof; (c) a second body having a polymer with a drug compounded therein and a barrier coating of polymeric material on the polymer such that the barrier coating can limit the rate of drug elution, the second body in the form of an open-ended, radially expandable tubular structure having an interior surface and an exterior surface, at least a portion of the polymer and barrier material exposed at the exterior surface thereof, said second tubular body mounted on the catheter at the distal end thereof; (d) means at the proximal end of the catheter for radially expanding the first and second tubular bodies to bring self-supporting structure of the first tubular body into coaxial supporting contact with the interior surface of the second tubular body such that the polymer and barrier material exposed at the exterior surface of the second tubular body contacts an interior portion of the body lumen to be treated. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 70, 71)
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44. A device for local intralumenal administration of drugs comprising:
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(a) a catheter having proximal and distal ends; (b) a first body in the form of an open-ended, radially expandable, self-supporting tubular structure, said first tubular body mounted on the catheter at the distal end thereof; (c) a second body having a polymer with a drug compounded therein, the second body in the form of a helically wound, open-ended, radially expandable tubular structure having an interior surface and an exterior surface and a first end and a second end, the second tubular body being variable in radial diameter under axial movement of the first and second ends relative to each other and having at least a portion of the polymer exposed at the exterior surface, said second tubular body mounted on the catheter at the distal end thereof; (d) means at the proximal end of the catheter for radially expanding the first and second tubular bodies to bring the self-supporting tubular structure of the first tubular body into coaxial supporting contact with the interior surface of the second tubular body such that the polymer exposed at the exterior surface of the second tubular body contacts an interior portion of the body lumen to be treated. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 72, 73)
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Specification