Intralumenal drug eluting prosthesis
First Claim
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1. A device for local intralumenal administration of drugs comprising:
- (a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other;
(b) a flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body;
(c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated; and
(d) a radially expandable stent of malleable metal in supporting contact with the tubular structure.
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Abstract
A prosthesis for insertion into a lumen to limit restenosis of the lumen. The prosthesis carries restenosis-limiting drugs which elute after the device is positioned in the lumen.
170 Citations
9 Claims
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1. A device for local intralumenal administration of drugs comprising:
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(a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other; (b) a flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body; (c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated; and (d) a radially expandable stent of malleable metal in supporting contact with the tubular structure.
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2. A device for local intralumenal administration of drugs comprising:
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(a) a body including a plurality of support elements forming a open-ended, radially expandable, self-supporting tubular structure having an interior surface and an exterior surface, the tubular structure including as support elements a plurality of helical elements, each of which is wound in a helix configuration along a center line of the tubular body as a common axis, said helical elements wound in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other; (b) a flexible, polymeric filament attached to the support elements of the body, at least a portion of the filament exposed at an exterior surface of the tubular body; (c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated; and (d) a radially expandable stent of resilient metal in supporting contact with the tubular structure.
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3. A device for local intralumenal administration of drugs comprising:
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(a) a body including a plurality of bioabsorbable polymeric elements forming an open-ended, radially expandable tubular structure having an interior surface and an exterior surface, the tubular structure including a plurality of elements joined together such that the tubular body is variable in radial diameter; (b) a flexible, bioabsorbable polymeric filament attached to the elements of the body such that at least a portion of the filament is exposed at an exterior surface of the tubular body; (c) a drug compounded into the polymeric filament such that the drug is delivered to the body lumen when the tubular body is radially expanded into contact with the portion of the body lumen to be treated; and (d) a radially expandable metal stent in supporting contact with the tubular body. - View Dependent Claims (4, 5, 6, 7, 8, 9)
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Specification