Hygienic agent for use in hemodialysis

• US 5,851,483 A
• Filed: 02/16/1995
• Issued: 12/22/1998
• Est. Priority Date: 11/23/1988
• Status: Expired due to Fees

• Current Assignee: L'Air Liquide Societe Anonyme Pour L'Etude et L'Exploitation Des Procedes Georges Claude (L'Air Liquide SA)
• Original Assignee: L'Air Liquide Societe Anonyme Pour L'Etude et L'Exploitation Des Procedes Georges Claude (L'Air Liquide SA)
• Inventors: Nicolle, Remy, Jourdan-Laforte, Eric
• Primary Examiner(s): TRAN, HIEN THI
• Application Number:
  US08/389,971
• Time in Patent Office: 1,405 Days
• Field of Search: 422/6, 422/7, 422/17, 422/28, 422/29, 422/31, 422/44, 210/96.2, 210/636, 210/644, 210/646, 210/647, 210/645, 210/805, 210/806, 514/832, 514/833, 514/839, 514/840, 514/857, 424/616, 424/613
• US Class Current: 422/28
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/16 containing the group; Thio analogues thereof
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A61L 2/18 Liquid substances or solutions comprising solids or dissolved gases

Abstract

The invention concerns a hygienic agent for use in hemodialysis. This hygienic agent based on peracetic acid has an aqueous solution containing 6 to 8 weight % hydrogen peroxide, 0.1 to 1 weight % peracetic acid and 2 to 10 weight % acetic acid. Application to the disinfection, sterilization of dialysis generators, dialyzers, hemofilters and hemodialyzers and circuits of water treatment for hemodialysis.

Claims

1. A method of disinfecting and removing tartar from interior portions of a dialysis generator, the method comprising the steps of:

introducing into the dialysis generator a sterilization composition consisting essentially of an aqueous solution of 6 to 8 percent by weight hydrogen peroxide, 0.3 to 0.4 percent by weight peracetic acid, and 3.5 to 4.5 percent by weight acetic acid, the composition remaining stable for at least a year;

adjusting the dialysis generator so that the sterilization composition is automatically diluted in water by the ratio of composition-to-water of 1;

10 to 1;

35 to provide a diluted cleaning composition and so that the diluted composition is placed in contact with the interior portions of the dialysis generator for a period of 20 to 30 minutes; and

rinsing the contacted interior portions of the dialysis generator with osmotic water for a period of about 30 minutes.

2. The method of claim 1, wherein the sterilization composition consists essentially of an aqueous solution of 7 percent by weight hydrogen peroxide, 0.35 percent by weight peracetic acid, and 3.5 to 4 percent by weight acetic acid.

3. A method of disinfecting and removing tartar from water treatment circuits of dialysis equipment, the method comprising the steps of:

diluting a sterilization composition which remains stable for at least a year and which consists essentially of an aqueous solution of 6 to 8 percent by weight hydrogen peroxide, 0.3 to 0.4 percent by weight peracetic acid, and 3.5 to 4.5 percent by weight acetic acid in water by the ratio of composition-to-water of 1;

10 to 1;

35 to provide a diluted composition;

placing the diluted composition in contact with the water treatment circuits of the dialysis equipment for a period of about 30 minutes; and

rinsing the contacted water treatment circuits with osmotic water for a period of 30 minutes to 2 hours.

4. The method of claim 3, wherein the sterilization composition consists essentially of an aqueous solution of 7 percent by weight hydrogen peroxide, 0.35 percent by weight peracetic acid, and 3.5 to 4 percent by weight acetic acid.

5. A method of disinfecting and removing tartar from interior portions of dialyzers, hemofilters and hemodialyzers, the method comprising the steps of:

diluting a sterilization composition, which remains stable for at least a year and which consists essentially of an aqueous solution of 6 to 8 percent by weight hydrogen peroxide, 0.3 to 0.4 percent by weight peracetic acid, and 3.5 to 4.5 percent by weight acetic acid in water by the ratio of composition-to-water of 1;

10 to 2;

7 to provide a diluted composition;

placing the diluted composition in contact with the interior portions of the dialyzers, hemofilters and hemodialyzers for a period of 20 to 30 minutes; and

rinsing the contacted interior portions of the dialysis generator with osmotic water for a period of about 30 minutes.

6. The method of claim 5, wherein the sterilization composition consists essentially of an aqueous solution of 7 percent by weight hydrogen peroxide, 0.35 percent by weight peracetic acid, and 3.5 to 4 percent by weight acetic acid.

7. A composition for disinfecting and removing tartar from dialysis equipment, consisting essentially of an aqueous solution of 6 to 8 percent by weight hydrogen peroxide, 0.3 to 0.4 percent peracetic acid, and 3.5 to 4.5 percent by weight acetic acid.

8. The composition according to claim 7, consisting essentially of an aqueous solution of about 7 percent by weight hydrogen peroxide, about 0.35 percent peracetic acid, and 3.5 to 4 percent by weight acetic acid.