Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same
First Claim
1. A polymer for the controlled release of an active ingredient, the polymer having the general formula Ax By Cz Sq wherein A is an imidazole group-bearing vinyl monomer, B is a hydroxyl group-bearing vinyl monomer, C is a carboxyl group-bearing vinyl monomer, and S is a vinyl monomer covalently bonded to an active ingredient through an amide or an ester;
- andx+y+z+q=1; and
x, y, z, q can vary such that 0<
x<
1, and 0<
q<
1, and y and z can vary between 0 to 1.
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Accused Products
Abstract
The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an active ingredient in response to pH. The process involves selecting a vinyl monomer to which the active ingredient molecule is covalently linked through a pendent group, and selecting monomers bearing catalytic groups. The active ingredient-bearing monomer and the catalytic group-containing monomer are brought in juxtaposition either by complexation or molecular imprinting, and then polymerized with a hydrophilic monomer and crosslinker under an inert atmosphere with a suitable polymerization initiator.
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Citations
23 Claims
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1. A polymer for the controlled release of an active ingredient, the polymer having the general formula Ax By Cz Sq wherein A is an imidazole group-bearing vinyl monomer, B is a hydroxyl group-bearing vinyl monomer, C is a carboxyl group-bearing vinyl monomer, and S is a vinyl monomer covalently bonded to an active ingredient through an amide or an ester;
- and
x+y+z+q=1; and
x, y, z, q can vary such that 0<
x<
1, and 0<
q<
1, and y and z can vary between 0 to 1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification