Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
First Claim
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1. A method for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell comprising exposing the cell to an amount of isolated Wnt polypeptide which is effective for enhancing proliferation or differentiation of the cell.
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Abstract
Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.
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20 Claims
- 1. A method for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell comprising exposing the cell to an amount of isolated Wnt polypeptide which is effective for enhancing proliferation or differentiation of the cell.
- 15. A method for repopulating blood cells in a mammal comprising administering to the mammal a therapeutically effective amount of a Wnt polypeptide.
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