Methods of preparing gas and gaseous precursor-filled microspheres
First Claim
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1. A method for preparing temperature activated gaseous precursor-filled lipid microspheres comprising shaking an aqueous solution comprising a lipid in the presence of a gaseous precursor at a temperature below the gel state to liquid crystalline state phase transition temperature of the lipid, wherein upon activation of said gaseous precursor to a gas the lipid microspheres have at least about 50% volume of gas in the interior thereof.
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Abstract
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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- 1. A method for preparing temperature activated gaseous precursor-filled lipid microspheres comprising shaking an aqueous solution comprising a lipid in the presence of a gaseous precursor at a temperature below the gel state to liquid crystalline state phase transition temperature of the lipid, wherein upon activation of said gaseous precursor to a gas the lipid microspheres have at least about 50% volume of gas in the interior thereof.
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