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Guanylhydrazones and their use to treat inflammatory conditions

  • US 5,854,289 A
  • Filed: 04/15/1996
  • Issued: 12/29/1998
  • Est. Priority Date: 01/21/1994
  • Status: Expired due to Term
First Claim
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1. A method for treating multiple sclerosis (autoimmune encephalomyelitis) comprising administering an effective amount of a compound or a pharmaceutically acceptable salt thereof having a formula:

  • ##STR5## wherein;

    X2 =GhyCH--, GhyCCH3 -- or H--;

    X1, X'"'"'1 and X'"'"'2, independently=GhyCH--, GhyCCH3 --;

    Z=--NH(CO)NH--, or --A--(CH2),--A--, n=2-10; and

    A=independently --NH(CO)--, --(CO)NH--, NH(CO)NH--, --NH-- or --O--.

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