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Pro-thiol aryl azide labelling of nucleic acids

  • US 5,854,409 A
  • Filed: 04/08/1997
  • Issued: 12/29/1998
  • Est. Priority Date: 11/27/1995
  • Status: Expired due to Term
First Claim
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1. A pro-thiol aryl azide for coupling a thiol group to a nucleic acid, said pro-thiol aryl azide having the structure:

  • ##STR40## wherein, R1 to R4, which may be the same or different, are selected from the group consisting of H, alkyl, nitro, hydroxy, halide, carboxylic acid, methoxy, cyano, amino groups and salts thereof;

    wherein E comprises an amine and salts thereof, and a chain of C1 -C20 having chain constituents selected from the group consisting of alkyl, alkenyl, alkynyl heteroatoms and salts thereof, said chain constituents having substituents selected from the group consisting of H, C1 -C6 alkyl, aryl, ester, ether, amine, amide, halo groups and salts thereof;

    and wherein Y is a group capable of protecting the sulfur moiety from chemical reaction and removable so as to generate a thiol moiety.

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