Biocompatible titanium implant

• US 5,855,612 A
• Filed: 05/10/1996
• Issued: 01/05/1999
• Est. Priority Date: 05/12/1995
• Status: Expired due to Fees

• Current Assignee: Akiyoshi Osaka, OHTA Company Limited
• Original Assignee: Akiyoshi Osaka, OHTA Company Limited
• Inventors: Ohthuki, Chikara, Iida, Hirohisa, Ohta, Keizo, Osaka, Akiyoshi
• Primary Examiner(s): Brittingham, Debra S.
• Assistant Examiner(s): Black, John M.
• Application Number:
  US08/644,747
• Time in Patent Office: 970 Days
• Field of Search: 623/11, 623/16, 623/18, 623/20, 623/22
• US Class Current: 424/423
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61F 2310/00023 Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: C23C 22/64 Treatment of refractory metals or alloys based thereon
• CPC Class Codes: C23C 22/68 using aqueous solutions with pH between 6 and 8

Abstract

A biocompatible titanium implant with a modified exterior surface having a covering layer that comprises a hydrated titania gel. The exterior surface of the titanium implant is processed by a hydrogen peroxide aqueous solution that contains metal ions which not only promotes a reaction between the titanium implant and the hydrogen peroxide aqueous solution but also provides a high apatite formation ability to the hydrated titania gel on the surface of the implant.

Claims

1. A biocompatible titanium implant with increased bioactivity comprising a covering layer on a surface thereof of hydrated titania gel that contains metal ions, said covering layer having increased affinity for apatite formation, said titanium implant being processed by a hydrogen peroxide aqueous solution which contains metal ions, said solution promotes a reaction on the surface of said titanium implant forming said covering layer whereby a layer of apatite is formed on said biocompatible titanium implant when placed in contact with body fluid and tissues to unify the titanium implant with the body tissues through said apatite layer, and wherein said metal ions are at least one selected from the group consisting of Ta and Sn.

3. A biocompatible titanium implant according to claim 1, wherein said metal ions are at least one selected from the group consisting of Ta, Sn, Ti, Si, Zr, Li and Na.

5. A biocompatible titanium implant according to claim 3, wherein a temperature of said hydrogen peroxide aqueous solution is 30°

-90°

C.

2. A biocompatible titanium implant with increased bioactivity comprising a layer on an exterior surface thereof, said layer being a hydrated titania gel obtained by immersing the titanium implant in a hydrogen peroxide aqueous solution, said solution contains metal ions selected from the group consisting of Ta and Sn whereby a layer of apatite is formed on said biocompatible titanium implant when placed in contact with body fluids and tissues to unify the titanium implant with the body tissues through said apatite layer.

4. A biocompatible titanium implant according to claim 2, wherein a concentration of said hydrogen peroxide aqueous solution is 5-30% by weight.