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Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change

  • US 5,855,613 A
  • Filed: 10/13/1995
  • Issued: 01/05/1999
  • Est. Priority Date: 10/13/1995
  • Status: Expired due to Term
First Claim
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1. A viable, physiologically active and biocompatible cellular or tissue implant for implantation in a host body, having a thin sheet configuration, comprising a purified biocompatible gelled alginate which does not produce any significant foreign body reaction or fibrosis and which has a thickness between about 10 μ

  • m and about 400 μ

    m, said implant having at least 100,000 cells, said cells being selected from the group consisting of pancreatic islet cells, renal cortex cells, parathyroid cells, thyroid cells, adrenal cells and hepatic cells, said implant having a permeability sufficient to inhibit diffusion and release of proteins having a molecular weight of greater than 300 kD from the implant into the host body, but permit effective diffusion and release of proteins having a molecular weight of not greater than 75 kD.

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