Biomatrix for soft tissue regeneration
First Claim
Patent Images
1. An implant for repair of a tissue defect in an animal in need thereof, which implant comprises:
- a contracted gel matrix; and
mesenchymal stem cells within said contracted gel matrix, said cells having contracted said gel matrix, said matrix having been contracted in tension in a given direction.
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Accused Products
Abstract
An implant for repair of a tissue defect which implant comprises a physiologically compatible load-bearing member having an element for securing under tension tissue adjacent to the defect to be repaired, an element for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The implant can be a suture material having a cell containing matrix surrounding a central portion thereof. The matrix is preferably a gel or other material which the cells cause to contract, thereby drawing together the tissues surrounding the defect to which the implant is attached.
466 Citations
20 Claims
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1. An implant for repair of a tissue defect in an animal in need thereof, which implant comprises:
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a contracted gel matrix; and mesenchymal stem cells within said contracted gel matrix, said cells having contracted said gel matrix, said matrix having been contracted in tension in a given direction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An implant for repair of a tissue defect in an animal in need thereof, which implant comprises:
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a contracted gel matrix; a suture embedded in said gel matrix along an axial direction between first and second spaced locations; said suture having first and second ends each extending beyond a different location externally said gel matrix; and mesenchymal stem cells within said gel matrix, said matrix having been contracted in tension in said axial direction in response to said cells. - View Dependent Claims (19)
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20. An implant for repair of a tissue defect in an animal in need thereof, which implant comprises:
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a cell contracted collagen gel matrix extending in an axial direction; a load bearing member contiguous with and attached to said gel matrix along said axial direction between first and second spaced locations for extending across said defect; and mesenchymal stem cells within said contracted gel matrix, said matrix having been contracted in tension in said axial direction in response to said cells.
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Specification