Polymorphisms in the glucose-6 phosphate dehydrogenase locus
First Claim
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1. An isolated nucleic acid segment of between 10 and 100 bases of which at least 10 contiguous bases including a polymorphic site are from a sequence selected from the group consisting of SEQ ID NOS:
- 1-5, SEQ ID No;
5 in which the C at position 10 is replaced by a G, SEQ ID No;
7, SEQ ID No;
7 in which the C at position 10 is replaced by a T, SEQ ID Nos;
16-18, SEQ ID No;
18 in which the G at position 10 is replaced by a T, SEQ ID Nos;
20-22, SEQ ID Nos;
24 and 25, SEQ ID No;
25 in which the G at position 10 is replaced by an A, SEQ ID Nos;
28 and 29, and the perfect complements thereof, wherein the polymorphic site occurs at position 10 in each of the SEQ. ID Nos.
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Abstract
The invention provides nucleic acid segments of the glucose-6 phosphate dehydrogenase locus of the human genome including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as forensics, paternity testing, medicine and genetic analysis.
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Citations
13 Claims
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1. An isolated nucleic acid segment of between 10 and 100 bases of which at least 10 contiguous bases including a polymorphic site are from a sequence selected from the group consisting of SEQ ID NOS:
- 1-5, SEQ ID No;
5 in which the C at position 10 is replaced by a G, SEQ ID No;
7, SEQ ID No;
7 in which the C at position 10 is replaced by a T, SEQ ID Nos;
16-18, SEQ ID No;
18 in which the G at position 10 is replaced by a T, SEQ ID Nos;
20-22, SEQ ID Nos;
24 and 25, SEQ ID No;
25 in which the G at position 10 is replaced by an A, SEQ ID Nos;
28 and 29, and the perfect complements thereof, wherein the polymorphic site occurs at position 10 in each of the SEQ. ID Nos. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 1-5, SEQ ID No;
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9. An isolated nucleic acid fragment of a human X chromosome comprising at least 10 contiguous bases including a polymorphic site from a sequence selected from the group consisting of SEQ ID Nos:
- 2 and 4, SEQ ID No;
5 in which the C at position 10 is replaced by a G, SEQ ID No;
7 in which the C at position 10 is replaced by a T, SEQ ID No;
17, SEQ. ID. No;
18 in which the G at position 10 is replaced by a T, SEQ ID NOS;
21 and 24, SEQ ID NO;
25 in which the G at position 10 is replaced by an A, SEQ ID NO;
29, and the perfect complements thereof, wherein the polymorphic site occurs at position 10 in each of the SEQ ID NOS. - View Dependent Claims (10)
- 2 and 4, SEQ ID No;
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11. A method of determining a base occupying a polymorphic site in a nucleic acid, comprising:
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obtaining the nucleic acid from an individual; and determining a base occupying a polymorphic site in a sequence selected from the group consisting of SEQ ID NOS;
2 and 4, SEQ ID NO;
5 in which the C at position 10 is replaced by a G, SEQ ID NO;
7 in which the C at position 10 is replaced by a T, SEQ ID NO;
17, SEQ. ID NO;
18 in which the G at position 10 is replaced by a T, SEQ ID NOS;
21 and 24, SEQ ID NO;
25 in which the G at position 10 is replaced by an A, SEQ ID NO;
29, and the perfect complements thereof, wherein the polymorphic site occurs at position 10 in each of the SEQ ID NOS. - View Dependent Claims (12, 13)
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Specification