Method for determination of item of interest in a sample

• US 5,856,194 A
• Filed: 09/19/1996
• Issued: 01/05/1999
• Est. Priority Date: 09/19/1996
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Mitchell, James E., Gardner, Gregory E., Fritchie, Patrick P., Galitz, Charles M., Toth, Julius J., Murray, David W., Dunn, Chadwick M., Gray, Robert C., Ramsey, Jack F., Luoma, Robert P. II, Arnquist, David C., Holen, James T., Grandone, Cass J., Barnes, Grady III, Murray, Adrian John, McCoy, Jimmy D., Sleszynski, Neal T., Button, Richard D., East, Richard C. Jr.
• Primary Examiner(s): Le, Long V.
• Application Number:
  US08/715,780
• Time in Patent Office: 838 Days
• Field of Search: 436/43, 436/47, 436/48, 436/49, 436/172, 436/50, 436/174, 436/177, 436/180, 436/807, 422/63, 422/64, 422/65, 422/67, 422/100, 422/104
• US Class Current: 436/50
• CPC Class Codes: G01N 2035/00534 Mixing by a special element, e.g. stirrer
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/0467 Switching points ("aiguillages")
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/115831 Condition or time responsive

Abstract

The embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

Claims

1. A method of performing a process for determining an item of interest in a sample, the method comprising the steps of:

(a) providing a process path comprising a process lane in which a reaction container is moved, the process lane diverging into a process step performance lane where a process step comprising the process for determining the item of interest in the sample is performed, and a process step avoidance lane where the process step performed at the process step performance lane is avoided such that the process step performance lane and the process step avoidance lane are disposed substantially side by side, both the process step performance lane and the process step avoidance lane converging to the process lane;

(b) moving the reaction container along the process lane;

(c) introducing the sample to the reaction container while the reaction container is in the process lane;

(d) introducing a reagent to the reaction container while the reaction container is in the process lane;

(e) mixing the sample and the reagent in the reaction container while the reaction container is in the process lane;

(f) selectively positioning the reaction container in a selected one of the process step performance lane and the process step avoidance lane based on whether the process step comprising the process for determining the item of interest in the sample is to be performed or not;

(g) returning the reaction container from one of the process step performance lane and the process step avoidance lane to the process lane; and

(h) determining the item of interest in the sample based upon a reaction between the sample and the reagent while the reaction container is in the process lane.

2. A method as defined in claim 1 further comprising the step of:

(i) removing fluid from the process path via a drain on the process path.

3. A method as defined in claim 1 further comprising the steps of:

(i) placing the container in a slot associated with the process path having a longitudinal axis; and

(j) moving the container within the slot along the longitudinal axis.

4. A method as defined in claim 3 further comprising the step of;

(k) removing the container from the slot.

5. A method as defined in claim 1 further comprising the steps of:

(i) moving the container from a container supply to a loading lane on the process path; and

(j) moving the container from the loading lane to the process lane.

6. A method as defined in claim 1 further comprising the step of:

(i) exposing the container to a magnet along the process lane.

7. A method as defined in claim 1 further comprising the step of;

(i) exposing the container to a wash station along the process lane.

8. A method as defined in claim 1 further comprising the step of:

(i) operatively connecting the process path with another process path.

9. A method of performing a process for determining an item of interest in a sample, the method comprising the steps of:

(a) providing a process path comprising a process lane accepting a reaction container holding the sample, the process lane diverging into a process step performance lane where a process step comprising the process for determining the item of interest in the sample is performed, and a process step avoidance lane where the process step performed at the process step performance lane is avoided such that the process step performance lane and the process step avoidance lane are disposed substantially side by side, both the process step performance lane and the process step avoidance lane converging to the process lane;

(b) introducing the reaction container to the process lane where sample and reagent are introduced to the reaction container and where a reaction between the sample and the reagent is read;

(c) selectively automatically positioning the reaction container in a selected one of the process step performance lane and the process step avoidance lane based on whether the process step comprising the process for determining the item of interest in the sample is to be performed or not; and

(d) returning the reaction container from the selected one of the process step performance lane and the process step avoidance lane to the process lane.

10. A method as defined in claim 9 further comprising the step of:

(e) removing fluid from the process path via drain on the process path.

11. A method as defined in claim 9 further comprising the steps of:

(e) placing the container in a slot having a longitudinal axis operatively associated with the process lane; and

(f) moving the container within the slot along the longitudinal axis of the slot.

12. A method as defined in claim 9 further comprising the step of:

(e) operatively connecting the process path with another process path.

13. A method as defined in claim 9 wherein the process step includes at least one of mixing container contents, magnetically separating container contents, removing a portion of the container contents from the container, and adding to the container contents.