Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof

• US 5,857,994 A
• Filed: 10/01/1996
• Issued: 01/12/1999
• Est. Priority Date: 10/01/1996
• Status: Expired due to Term

• Current Assignee: Vyteris, Inc.
• Original Assignee: Becton, Dickinson & Co
• Inventors: Flower, Ronald J.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US08/724,414
• Time in Patent Office: 833 Days
• Field of Search: 604/20, 604/115, 604/120, 604/149, 607/1, 607/72, 607/74, 606/32, 606/34
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0444 Membrane

Abstract

An iontophoretic drug delivery device includes a controller normally being in an off or low power consumption state, and a patch including electrodes, a reservoir containing an ionizable drug for transcutaneous delivery to a patient and a return reservoir. The patch is removably and electrically connectable to the controller, and delivers the drug to patient when the patch is on the patient'"'"'s skin and when the controller is switched from the off or low power consumption state to an operational state. This occurs when the patch is inserted into the controller. This feature preserves the battery of the controller. Upon patch insertion, the controller periodically changes from a non-current delivery state to a current delivery state for the predetermined period of time to deliver a pulse of current to the inserted patch. A current sensor within the controller measures the current delivered to the patch. The controller switches to the non-current delivering state if the amount of current drawn is less than a predetermined amount, and is therefore off the skin, and switches to the current delivering state otherwise. This feature prevents the build up of charge on the patch electrodes and the possibility of an uncomfortable electrical sensation.

Claims

1. An iontophoretic drug delivery device comprising:

a controller having a power source and a current generating circuit, said controller normally being in an off state;

a patch attachable to the skin of a patient, the patch including an anode and a cathode, one of said anode and said cathode including a reservoir containing an ionizable drug for transcutaneous delivery to the patient, said patch being removably, electrically connectable to said controller, said patch for delivering drugs to the patient when said controller is in an operational state and the patch is on the skin;

means for switching the off state to the operational state by the electrical connection of said patch to said controller.

2. A device according to claim 1, wherein said power source is electrically connected in series between one end of said current generating circuitry and a first terminal of said controller, and another end of said current generating circuitry is connected to a second terminal of said controller, and said patch includes a conductor for electrically connecting said first and second terminals of said controller when said patch is connected to said controller, thereby connecting the power source to the current generating circuitry and switching the off state to the operational state.

3. A device according to claim 2, wherein said power source is a battery.