Stent and therapeutic delivery system

• US 5,857,998 A
• Filed: 06/02/1997
• Issued: 01/12/1999
• Est. Priority Date: 06/30/1994
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Corporation
• Inventors: Barry, James
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/867,292
• Time in Patent Office: 589 Days
• Field of Search: 604/96, 604/101, 604/102, 604/52, 604/53, 604/103, 604/104, 604/49, 604/157-163, 604/8, 604/28, 606/192, 606/193, 606/194
• US Class Current: 604/103.03
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1093 having particular tip characteristics
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

Apparatus and a method for treating an irregularity in a wall of a vessel of a patient defined by an irregular or afflicted wall portion with adjacent normal wall portions comprises a catheter having a distal end portion for being guided through the vessel to the site of the irregularity. A balloon associated with said distal end portion of the catheter for selective inflating to contact the walls of the vessel urges a stent carried by the distal end portion of the catheter in a constricted condition for passage through the vessel into an expanded form with the stent spanning the afflicted wall portion and contacting the adjacent wall portions. The catheter is formed with lumens for inflating the balloon, for receiving a guidewire for guiding the catheter through the vessel, and for connecting a port in the catheter proximate the afflicted wall portion to enable delivery of a therapeutic agent into the vessel to contact the stent and the irregular wall portion.

Claims

1. A stent assembly for deployment within a patient'"'"'s body comprising:

A. frame means for defining the form of the assembly;

B. means supported by said frame means for defining a therapeutic agent reservoir and for enabling the seepage of a therapeutic agent in the therapeutic agent reservoir therefrom; and

C. port means connecting with said reservoir means for introducing a therapeutic agent into said therapeutic agent reservoir subsequent to deployment of the stent assembly in a patient'"'"'s body.

2. An assembly as recited in claim 1 wherein said means for defining a therapeutic agent reservoir comprises a porous membrane whereby the therapeutic agent received in said membrane seeps through said membrane and into the patient'"'"'s body.

3. An assembly as recited in claim 2 wherein said frame means comprises an expansible member adapted for insertion in a compact form into the patient'"'"'s body and for deployment in an expanded form in the patient'"'"'s body.

4. An assembly as recited in claim 3 wherein said porous membrane overlies said frame means whereby the therapeutic agent reservoir is contiguous with said frame means.

5. An assembly as recited in claim 4 wherein said porous membrane comprises a polymeric material.

6. An assembly as recited in claim 5 wherein said polymeric material is a hydrophilic polymer.

7. An assembly as recited in claim 5 wherein said polymeric material is a hydrophobic polymer.

8. An assembly as recited in claim 1 wherein said frame means comprises an expansible member adapted for insertion in a compact form into the patient'"'"'s body and for deployment in an expanded form in the patient'"'"'s body.

9. An assembly as recited in claim 8 wherein said means for defining the therapeutic agent reservoir overlies said frame means whereby the therapeutic agent reservoir is contiguous with said frame means.

10. An assembly as recited in claim 8 wherein said means for defining the therapeutic agent reservoir is formed of a hydrophilic material.

11. An assembly as recited in claim 1 wherein said means for defining the therapeutic agent reservoir is formed of a hydrophilic material.

12. A stent assembly for deployment within a patient'"'"'s body comprising:

A. frame means for defining the shape of the assembly;

B. reservoir means carried by said frame means for delivering a therapeutic agent from said stent; and

C. delivery means connected to said reservoir means for enabling addition of the therapeutic agent to said reservoir means in vivo.

13. A stent assembly as recited in claim 12 wherein said frame means comprises an expansible form for insertion into a patient'"'"'s body in a compact condition and for deployment in an expanded condition.

14. A stent assembly as recited in claim 13 wherein said reservoir means overlies said frame means.

15. A stent assembly as recited in claim 14 wherein said reservoir means comprises a hydrophilic membrane overlying said frame means to define thereby a reservoir for receiving the therapeutic agent.

16. A stent assembly as recited in claim 15 wherein said delivery means is a port formed in said membrane.

17. A stent assembly as recited in claim 12 wherein said reservoir means overlies said frame means.

18. A stent assembly as recited in claim 15 wherein said reservoir means comprises a polymeric membrane overlying said frame means to define thereby a reservoir for receiving the therapeutic agent.

19. A stent assembly as recited in claim 18 wherein said polymeric membrane is composed of a hydrophilic material.

20. A stent assembly as recited in claim 18 wherein said polymeric membrane is composed of a hydrophobic material.

21. A stent assembly as recited in claim 16 wherein said delivery means is a port formed in said membrane.

22. A stent assembly as recited in claim 12 wherein said reservoir means includes a hydrophilic membrane supported by said frame means to define thereby a reservoir for receiving the therapeutic agent.

23. A stent assembly as recited in claim 22 wherein said delivery means is a port formed in said membrane.

24. A therapeutic agent delivery system for replenishing a reservoir of a replenishable stent comprising:

A. insertion means having a distal end for inserting within the body of a patient and a proximal end for control by an operator of said insertion means;

B. transfer means proximate the distal end of said insertion means for connecting with the reservoir;

C. lumen means in said insertion means for connecting said transfer means with the proximal end of said insertion means; and

D. means associated with the proximal end of said insertion means for urging a therapeutic agent through said lumen means and transfer means to enable thereby replenishment of the reservoir of the replenishable stent.

25. A therapeutic agent delivery system as recited in claim 24 wherein said insertion means comprises a catheter-like tubular member.

26. A therapeutic agent delivery system as recited in claim 25 wherein said transfer means comprising a fitting corresponding to and mating with a fitting connected with the reservoir of the replenishable stent.